ArticleThe Journal of clinical investigation1995
Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 179 citations in OpenAlex.
- Dihydropyridine Calcium Channel Blockers and Kidney Outcomes.Journal of general internal medicine · 2024Article
- Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease.Frontiers in systems biology · 2024Article
- Paradigm Shift in Hyperglycemic Glomerular Hyperfiltration: Blunted Tubuloglomerular Feedback or Preglomerular Vasodilation?Hypertension (Dallas, Tex. : 1979) · 2023Article
- Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease.American journal of physiology. Renal physiology · 2022Review
- Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling.American journal of physiology. Renal physiology · 2021Article
- Circadian rhythm of the intrarenal renin-angiotensin system is caused by glomerular filtration of liver-derived angiotensinogen depending on glomerular capillary pressure in adriamycin nephropathy rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Aging Impairs Renal Autoregulation in Mice.Hypertension (Dallas, Tex. : 1979) · 2020Article
- BP Fluctuations and the Real-Time Dynamics of Renal Blood Flow Responses in Conscious Rats.Journal of the American Society of Nephrology : JASN · 2020Article
- Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Dihydropyridine calcium channel blockers in the elderly with diabetic nephropathy: Are they safe?Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Increased nocturnal blood pressure variability is associated with renal arteriolar hyalinosis in normotensive patients with IgA nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2017Review
- Circadian rhythm of blood pressure and the renin-angiotensin system in the kidney.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Review
- Article
- Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.American journal of physiology. Renal physiology · 2015Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2015Article
- Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Molecular mechanisms of renal blood flow autoregulation.Current vascular pharmacology · 2014Review
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hypertensive mechanisms are postulated to play a major role in the progressive glomerulosclerosis (GS) after renal mass reduction. But, in contrast to converting enzyme inhibitors, BP reduction by calcium channel blockers, has not provided consistent protection. Radiotelemetric BP monitoring for 7 wk was used to compare nifedipine (N) and enalapril (E) in the rat approximately 5/6 renal ablation model. After the first week, rats received N, E, or no treatment (C). The overall averaged systolic BP in C (173 +/- 7 mmHg) was reduced by both E and N (P < 0.001), but E was more effective (113 +/- 2 vs. 134 +/- 3 mmHg, P < 0.01). GS was prevented by E (2 +/- 1 vs. 26 +/- 5% in C) but not by N (25 +/- 6%). GS correlated well with the overall averaged BP in individual animals of all groups, but the slope of the relationship was significantly steeper in N compared with C+E rats (P < 0.02), suggesting greater pressure transmission to the glomeruli and GS for any given BP. Since autoregulatory mechanisms provide the primary protection against pressure transmission, renal autoregulation was examined at 3 wk in additional rats. Autoregulation was impaired in C rats, was not additionally altered by E, but was completely abolished by N. These data demonstrate the importance of autoregulatory mechanisms in the pathogenesis of hypertensive injury and suggest that calcium channel blockers which adversely affect pressure transmission may not provide protection despite significant BP reduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.