ArticleThe Journal of clinical investigation1995
Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 191 citations in OpenAlex.
- Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review.Journal of human hypertension · 2016Pooled it
- Pooled it
- Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations.Epigenetics · 2025Article
- Case-control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians.Journal of genetics · 2016Article
- Article
- Gender specific association of RAS gene polymorphism with essential hypertension: a case-control study.BioMed research international · 2014Article
- Hypercontrols in genotype-phenotype analysis reveal ancestral haplotypes associated with essential hypertension.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Variants and haplotypes in angiotensinogen gene are associated with plasmatic angiotensinogen level in Mexican population.The American journal of the medical sciences · 2011Article
- Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese.Journal of hypertension · 2010Article
- A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Genetics of arterial hypertension and hypotension.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- Familial aggregation of insulin resistance and cardiovascular risk factors in hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2006Article
- Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study.BMC cardiovascular disorders · 2005Article
- A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity.Journal of molecular medicine (Berlin, Germany) · 2005Article
- The genetic basis for altered blood vessel function in disease: large artery stiffening.Vascular health and risk management · 2005Review
- Role of two angiotensinogen polymorphisms in blood pressure variation.Journal of human hypertension · 2004Article
- Association between evolutionary history of angiotensinogen haplotypes and plasma levels.Human genetics · 2004Article
- AGT and RH blood group polymorphisms affect blood pressure and lipids in Afro-Caribbeans.Journal of human hypertension · 2004Article
- Genes of renin angiotensin system and coronary heart disease.Indian journal of clinical biochemistry : IJCB · 2000Article
- Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The renin-angiotensin system regulates blood pressure and sodium balance. The angiotensinogen gene which encodes the key substrate within this system has been linked to essential hypertension in White Europeans. It has been suggested that people of West African ancestry may have a different genetic basis for hypertension. In this study we have tested whether there is linkage of the angiotensinogen gene to essential hypertension in African Caribbeans from St. Vincent and the Grenadines. DNA from 63 affected sibling pairs with hypertension was tested for linkage by analyzing whether there was excess allele sharing among siblings genotyped using an angiotensinogen dinucleotide repeat sequence. There was significant support for linkage (T = 3.07, P = 0.001) and association of this locus to hypertension (chi 2 = 50.2, 12 degrees of freedom, P << 0.001). A DNA polymorphism which alters methionine to threonine at position 235 (M235T) within the angiotensinogen peptide has been associated previously with hypertension. However, we found no association of this variant with hypertension in this study. These findings provide support for linkage and association of the angiotensinogen locus to hypertension in African Caribbeans and suggest some similarities in the genetic basis of essential hypertension in populations of different ethnicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.