ArticleThe Journal of clinical investigation1995
Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 148 citations in OpenAlex.
- Therapeutic Investigation of Palm Oil Mill Effluent-Derived Beta-Carotene in Streptozotocin-Induced Diabetic Retinopathy via the Regulation of Blood-Retina Barrier Functions.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?Current diabetes reviews · 2022Review
- Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study.Journal of diabetes investigation · 2021Article
- The molecular mechanisms of copper metabolism and its roles in human diseases.Pflugers Archiv : European journal of physiology · 2020Review
- Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Copper transporters and copper chaperones: roles in cardiovascular physiology and disease.American journal of physiology. Cell physiology · 2018Review
- Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.International journal of molecular sciences · 2017Review
- The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications.Diseases (Basel, Switzerland) · 2016Review
- The association of serum vascular endothelial growth factor and ferritin in diabetic microvascular disease.Diabetes technology & therapeutics · 2014Article
- Diabetic macular edema: new concepts in patho-physiology and treatment.Cell & bioscience · 2014Review
- Neurotoxic effects of iron overload under high glucose concentration.Neural regeneration research · 2013Article
- Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease.Antioxidants & redox signaling · 2013Article
- Article
- Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.Biochemistry · 2011Article
- Review
- Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice.Experimental diabetes research · 2011Article
- Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Article
- Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Antioxidants & redox signaling · 2010Review
- Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats.Diabetes · 2008Article
- Effect of cartilage oligomeric matrix protein angiopoietin-1 on peripheral nerves in db/db diabetic mice.Current therapeutic research, clinical and experimental · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oxygen free radical activity is elevated in diabetes mellitus and has been implicated in the etiology of vascular complications. Recent studies have shown that impaired perfusion of nerve endoneurium is a major cause of nerve fiber dysfunction in experimental diabetes. Free radical scavenger treatment prevents the development of nerve conduction abnormalities in diabetic rats. In vitro experiments suggest that autoxidation reactions of glucose, catalyzed by free transition metal ions, are a potential source of free radicals in diabetes. We investigated whether chronic treatment with deferoxamine and trientine, transition metal chelating agents which can prevent autoxidation, could correct nerve conduction and blood flow changes in streptozotocin-diabetic rats. A 20% reduction in sciatic nerve motor conduction velocity after 2 mo diabetes was 90% ameliorated by 2 wk of treatment with deferoxamine or trientine. Sciatic endoneurial nutritive blood flow was 45% reduced by diabetes, but was completely corrected by treatment. In contrast, transition metal chelation had no effect on blood flow or conduction velocity in nondiabetic rats. Thus, the data support the hypothesis that increased free radical activity by glucose autoxidation as a result of impaired transition metal handling is a major cause of early neurovascular deficits in diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.