ArticleJournal of bacteriology1995
Contribution of gentamicin 2'-N-acetyltransferase to the O acetylation of peptidoglycan in Providencia stuartii.
Article in Journal of bacteriology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- The newly identifiedAntimicrobial agents and chemotherapy · 2025Article
- Identification and Characterization of a Novel Chromosomal Aminoglycoside 2'-Frontiers in microbiology · 2021Article
- Small-Molecule Acetylation by GCN5-RelatedMicrobiology and molecular biology reviews : MMBR · 2020Review
- Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles.Frontiers in microbiology · 2019Article
- Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.ACS infectious diseases · 2018Article
- Emergence and spread of antibiotic resistance: setting a parameter space.Upsala journal of medical sciences · 2014Review
- Wide variation in antibiotic resistance proteins identified by functional metagenomic screening of a soil DNA library.Applied and environmental microbiology · 2012Article
- Quinolone resistance: much more than predicted.Frontiers in microbiology · 2011Article
- The vertebrate lysozyme inhibitor Ivy functions to inhibit the activity of lytic transglycosylase.The Journal of biological chemistry · 2010Article
- Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Mutations affecting peptidoglycan acetylation in Neisseria gonorrhoeae and Neisseria meningitidis.Infection and immunity · 2005Article
- Versatility of aminoglycosides and prospects for their future.Clinical microbiology reviews · 2003Review
- Overexpression and characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.Antimicrobial agents and chemotherapy · 2001Article
- Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.Antimicrobial agents and chemotherapy · 2000Article
- Activation of the 2'-N-acetyltransferase gene [aac(2')-Ia] in Providencia stuartii by an interaction of AarP with the promoter region.Antimicrobial agents and chemotherapy · 1999Article
- Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase.Antimicrobial agents and chemotherapy · 1998Article
- Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii.Journal of bacteriology · 1998Article
- Loss of intrinsic aminoglycoside resistance in Acinetobacter haemolyticus as a result of three distinct types of alterations in the aac(6')-Ig gene, including insertion of IS17.Antimicrobial agents and chemotherapy · 1997Article
- An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.Antimicrobial agents and chemotherapy · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A collection of Providencia stuartii mutants which either underexpress or overexpress aac(2')-Ia, the chromosomal gene coding for gentamicin 2'-N-acetyltransferase (EC 2.3.1.59), have been characterized phenotypically as possessing either lower or higher levels of peptidoglycan O acetylation, respectively, than the wild type. These mutants were subjected to both negative-staining and thin-section electron microscopy. P. stuartii PR100, with 42% O acetylation of peptidoglycan compared with 52% O acetylation in the wild type, appeared as irregular rods. In direct contrast, P. stuartii strains PR50.LM3 and PR51, with increased levels of peptidoglycan O acetylation (65 and 63%, respectively), appeared as coccobacilli and chain formers, respectively. Membrane blebbing was also observed with the chain-forming strain PR51. Thin sectioning of this mutant indicated that it was capable of proper constriction and separation. P. stuartii PM1, when grown to mid-exponential phase, did not have altered peptidoglycan O-acetylation levels, and cellular morphology remained similar to that of wild-type strains. However, continued growth into stationary phase resulted in a 15% increase in peptidoglycan O acetylation concomitant with a change of some cells from a rod-shaped to a coccobacillus-shaped morphology. The fact that these apparent morphological changes were directly related to levels of O acetylation support the view that this modification plays a role in the maintenance of peptidoglycan structure, presumably through the control of autolytic activity.
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