ArticleHuman genetics1995
Distribution of human endogenous retrovirus HERV-K genomes in humans and different primates.
Article in Human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- 'Cannibalism' of exogenous DNA sequences: The ancestral form of adaptive immunity which entails recognition of danger.Frontiers in immunology · 2022Review
- Review
- Reconstruction of the cell entry pathway of an extinct virus.PLoS pathogens · 2018Article
- Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein.Journal of virology · 2016Article
- Genome-wide amplification of proviral sequences reveals new polymorphic HERV-K(HML-2) proviruses in humans and chimpanzees that are absent from genome assemblies.Retrovirology · 2015Article
- The decline of human endogenous retroviruses: extinction and survival.Retrovirology · 2015Article
- Article
- Viral ancestors of antiviral systems.Viruses · 2011Review
- A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.Genome research · 2010Article
- Cross-sectional dating of novel haplotypes of HERV-K 113 and HERV-K 115 indicate these proviruses originated in Africa before Homo sapiens.Molecular biology and evolution · 2009Article
- Murine MusD retrotransposon: structure and molecular evolution of an "intracellularized" retrovirus.Journal of virology · 2007Article
- Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements.Genome research · 2006Article
- Identification of a functional envelope protein from the HERV-K family of human endogenous retroviruses.Journal of virology · 2005Article
- The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.Journal of virology · 2005Article
- Retrovirus restriction by TRIM5alpha variants from Old World and New World primates.Journal of virology · 2005Article
- Evolutionary spread and recombination of porcine endogenous retroviruses in the suiformes.Journal of virology · 2005Article
- Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: implications for human and viral evolution.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Relative age of proviral porcine endogenous retrovirus sequences in Sus scrofa based on the molecular clock hypothesis.Journal of virology · 2003Article
- Demystified. Human endogenous retroviruses.Molecular pathology : MP · 2003Review
- Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice.Journal of virology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of the human endogenous retrovirus (HERV)-K genome was investigated by Southern-blot analyses using a HERV-K-env DNA probe. With the exception of one DNA-sample, obtained from a Chinese individual in whom an amplification of HERV-K was detected, Southern-blot analyses yielded identical hybridization patterns with DNA from peripheral blood lymphocytes of 37 normal healthy blood donors, with DNA from six tumor cell lines, or with 23 DNA samples prepared from various carcinoma tissues. To elucidate whether the integration of HERV-K genomes into the primate lineage occurred as a single event or as an integration with later expansion, we further examined the evolutionary history of HERV-K by Southern blot analyses with DNA samples from different primate species. We detected HERV-K genomes in Macaca mulatta and Macaca silenus, which represent Old World monkeys, but not in prosimians (Galago demidovii) and New World monkeys, represented by Saguinus fuscicollis, Saguinus oedipus, and Callithrix iacchus. Thus, we assume that the infection of the primate lineage with HERV-K had occurred after the divergence of New World and Old World monkeys, but before the evolutionary expansion of large hominoids. In contrast to the apparent lack of HERV-K-env sequences in DNA from tissue of the New World monkey Saguinus oedipus (cotton-top marmoset), we found HERV-K-DNA in the B95-8 cell-line, which is a Saguinus oedipus leukocyte cell-line, immortalized in vitro by Epstein-Barr virus (EBV) and cultivated in human cells. It may be speculated that HERV-K-DNA or HERV-K-particles were introduced into these cells during in vitro transformation with EBV.
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