ArticleGenetics1995
Recombination of Ty elements in yeast can be induced by a double-strand break.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements.PLoS genetics · 2023Article
- The effect of hybridization on transposable element accumulation in an undomesticated fungal species.eLife · 2020Article
- Meiotic Chromosome Association 1 Interacts with TOP3α and Regulates Meiotic Recombination in Rice.The Plant cell · 2017Article
- Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes.Nucleus (Austin, Tex.) · 2017Review
- Review
- Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination.PLoS genetics · 2010Article
- From the shards of a shattered genome, diversity.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Double-strand breaks associated with repetitive DNA can reshape the genome.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks.Molecular and cellular biology · 2004Article
- Compartmentalization of the yeast meiotic nucleus revealed by analysis of ectopic recombination.Genetics · 2004Article
- ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Molecular dissection of mitotic recombination in the yeast Saccharomyces cerevisiae.Molecular and cellular biology · 2003Article
- Dasheng: a recently amplified nonautonomous long terminal repeat element that is a major component of pericentromeric regions in rice.Genetics · 2002Article
- A double-strand break in a chromosomal LINE element can be repaired by gene conversion with various endogenous LINE elements in mouse cells.Molecular and cellular biology · 2000Article
- Retrotransposon BARE-1 and Its Role in Genome Evolution in the Genus Hordeum.The Plant cell · 1999Article
- Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1999Review
- Analysis of repair and mutagenesis of chromium-induced DNA damage in yeast, mammalian cells, and transgenic mice.Environmental health perspectives · 1998Article
- Effects of DNA double-strand and single-strand breaks on intrachromosomal recombination events in cell-cycle-arrested yeast cells.Genetics · 1998Article
- The Saccharomyces cerevisiae RAD9 checkpoint reduces the DNA damage-associated stimulation of directed translocations.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ty retrotransposons are the main family of dispersed repeated sequences in the yeast Saccharomyces cerevisiae. These elements are flanked by a pair of long terminal direct repeats (LTRs). Previous experiments have shown that Ty elements recombine at low frequencies, despite the fact that they are present in 30 copies per genome. This frequency is not highly increased by treatments that cause DNA damage, such as UV irradiation. In this study, we show that it is possible to increase the recombination level of a genetically marked Ty by creating a double-strand break in it. This break is repaired by two competing mechanisms: one of them leaves a single LTR in place of the Ty, and the other is a gene conversion event in which the marked Ty is replaced by an ectopically located one. In a strain in which the marked Ty has only one LTR, the double-strand break is repaired by conversion. We have also measured the efficiency of repair and monitored the progression of the cells through the cell-cycle. We found that in the presence of a double-strand break in the marked Ty, a proportion of the cells is unable to resume growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.