ArticleGenetics1995
Genetic characterization of ms (3) K81, a paternal effect gene of Drosophila melanogaster.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
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- The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo.Molecular biology and evolution · 2017Article
- The Deadbeat Paternal Effect of Uncapped Sperm Telomeres on Cell Cycle Progression and Chromosome Behavior in Drosophila melanogaster.Genetics · 2016Article
- The intimate genetics of Drosophila fertilization.Open biology · 2015Review
- Protection of Drosophila chromosome ends through minimal telomere capping.Journal of cell science · 2015Article
- Sperm should evolve to make female meiosis fair.Evolution; international journal of organic evolution · 2015Article
- Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins.PloS one · 2015Article
- Mixed asexual and sexual reproduction in the Indo-Pacific reef coral Pocillopora damicornis.Ecology and evolution · 2013Article
- New genes as drivers of phenotypic evolution.Nature reviews. Genetics · 2013Review
- Repeated evolution of testis-specific new genes: the case of telomere-capping genes in Drosophila.International journal of evolutionary biology · 2012Article
- Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo.Genetics · 2011Article
- Paternal imprint essential for the inheritance of telomere identity in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Recent origins of sperm genes in Drosophila.Molecular biology and evolution · 2008Article
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- The generation of cloned Drosophila melanogaster.Genetics · 2005Article
- The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vast majority of known male sterile mutants of Drosophila melanogaster fail to produce mature sperm or mate properly. The ms(3) K81(1) mutation is one of a rare class of male sterile mutations in which sterility is caused by developmental arrest after sperm entry into the egg. Previous studies showed that males homozygous for the K81(1) mutation produce progeny that arrest at either of two developmental stages. Most embryos arrest during early nuclear cycles, whereas the remainder are haploid embryos that arrest at a later stage. This description of the mutant phenotype was based on the analysis of a single allele isolated from a natural population. It was therefore unclear whether this unique paternal effect phenotype reflected the normal function of the gene. The genetic analysis and initial molecular characterization of five new K81 mutations are described here. Hemizygous conditions and heteroallelic combinations of the alleles were associated with male sterility caused by defects in embryogenesis. No other mutant phenotypes were observed. Thus, the K81 gene acted as a strict paternal effect gene. Moreover, the biphasic pattern of developmental arrest was common to all the alleles. These findings strongly suggested that the unusual embryonic phenotype caused by all five new alleles was due to loss of function of the K81+ gene. The K81 gene is therefore the first clear example of a strict paternal effect gene in Drosophila. Based on the embryonic lethal phenotypes, we suggest that the K81+ gene encodes a sperm-specific product that is essential for the male pronucleus to participate in the first few embryonic nuclear divisions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.