ArticleGenetics1995
Regulation of HIS4 expression by the Saccharomyces cerevisiae SIN4 transcriptional regulator.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
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- Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.The Plant cell · 2017Article
- Facilitated assembly of the preinitiation complex by separated tail and head/middle modules of the mediator.Journal of molecular biology · 2012Article
- Understanding large multiprotein complexes: applying a multiple allosteric networks model to explain the function of the Mediator transcription complex.Journal of cell science · 2010Article
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- Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae.Molecular and cellular biology · 2007Article
- TATA-binding protein mutants that are lethal in the absence of the Nhp6 high-mobility-group protein.Molecular and cellular biology · 2004Article
- A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Molecular and cellular biology · 2003Article
- The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II.Genes & development · 2001Article
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- In vivo requirement of activator-specific binding targets of mediator.Molecular and cellular biology · 2000Article
- Genetic analysis of the YDR1-BUR6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast.Molecular and cellular biology · 2000Article
- Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chlorides.Antimicrobial agents and chemotherapy · 2000Article
- Chromatin opening and transactivator potentiation by RAP1 in Saccharomyces cerevisiae.Molecular and cellular biology · 1999Article
- Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation.Molecular and cellular biology · 1999Article
- Mediator protein mutations that selectively abolish activated transcription.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription.Molecular and cellular biology · 1998Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
- Genomic footprinting of the yeast zinc finger protein Rme1p and its roles in repression of the meiotic activator IME1.Nucleic acids research · 1998Article
- Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yeast SIN4 gene functions in the transcriptional activation and repression of diverse yeast genes. Previous experiments suggest a sin4 mutation affects chromatin structure and thus alters transcriptional regulation. In this report we show that SIN4 is required for full expression of the HIS4, Ty1, and MAT alpha genes, in addition to the previously described SIN4-dependence of CTS1 expression. All of these genes contain within their promoters a binding site for the Rap1p transcriptional regulator. However, SIN4 does not play a direct role either in transcriptional activation or repression by Rap1p. The HIS4 gene can be activated by either of two pathways, the basal or the inducible pathway, and experiments are described that show that a sin4 mutation affects both pathways. It was shown previously that mutation of the Rap1p binding site in the HIS4 promoter causes a similar effect on HIS4 expression and that this promoter mutation also causes a change in chromatin structure. The SNF2/SWI2 gene is also required for full HIS4 expression, and we show that a sin4 snf2 double mutant is not synergistic compared to either single mutant. We show that nucleosomes are positioned at the HIS4 promoter and that this positioning is disrupted in a snf2 mutant but not in a sin4 mutant. These findings suggest that SIN4 plays a distinct role in transcriptional regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.