Evidence map›Paper›PMID 7634154›Full record

ArticleHistochemistry and cell biology1995

Histochemical localization of heart-type fatty-acid binding protein in human and murine tissues.

W Zschiesche, A H Kleine, E Spitzer, J H Veerkamp, J F Glatz

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 72 citations in OpenAlex.

  1. Advances in biomarkers for myocardial injury after non-cardiac surgery.Journal of anesthesia and translational medicine · 2026
    Review
  2. Structural Insights into Mouse H-FABP.Life (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Review
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  6. Proteomics in gastroparesis: unique and overlapping protein signatures in diabetic and idiopathic gastroparesis.American journal of physiology. Gastrointestinal and liver physiology · 2019
    Article
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  20. Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2005
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

W ZschiescheMax-Delbrück-Centre of Molecular Medicine, Berlin, Germany.
A H Kleine
E Spitzer
J H Veerkamp
J F Glatz
Maastricht University · NLMax Delbrück Center · DERadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular fatty acid-binding proteins (FABP) are a highly conserved family of proteins consisting of several subtypes, among them the mammary-derived growth inhibitor (MDGI) which is quite homologous to or even identical with the heart-type FABP (H-FABP). The FABPs and MDGI have been suggested to be involved in intracellular fatty acid metabolism and trafficking. Recently, evidence for growth and differentiation regulating properties of MDGI and H-FABP was provided. Using four affinity-purified polyclonal antibodies against bovine and human antigen preparations, the cellular localization of MDGI/H-FABP in human and mouse tissues and organs was studied. The antibodies were weakly cross-reactive with adipose tissue extracts known to lack H-FABP, but failed to react by Western blot analysis with liver-type FABP (L-FABP) and intestinal-type FABP (I-FABP). MDGI/H-FABP protein was mainly detected in myocardium, skeletal and smooth muscle fibres, lipid and/or steroid synthesising cells (adrenals, Leydig cells, sebaceous glands, lactating mammary gland) and terminally differentiated epithelia of the respiratory, intestinal and urogenital tracts. The results provide evidence that expression of H-FABP is associated with an irreversibly postmitotic and terminally differentiated status of cells. Since all the antisera employed showed spatially identical and qualitatively equal immunostaining, it is suggested that human, bovine and mouse MDGI/H-FABP proteins share highly homologous epitopes.

Indexed as

Neoplasm ProteinsNerve Tissue ProteinsTumor Suppressor ProteinsAnimalsBlotting, WesternCarrier ProteinsCattleFatty Acid Binding Protein 3Fatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFatty AcidsFemaleGrowth InhibitorsHumansImmunohistochemistryMaleCarrier ProteinsFABP1 protein, humanFabp1 protein, mouseFABP3 protein, humanFabp3 protein, mouseFabp5 protein, mouseFABP7 protein, humanFabp7 protein, mouseFatty Acid Binding Protein 3Fatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFatty AcidsGrowth InhibitorsNeoplasm ProteinsNerve Tissue ProteinsPeptidesRecombinant ProteinsTumor Suppressor Proteins

Identifiers

PMID7634154
OpenAlexW2116798413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.