ReviewJournal of molecular medicine (Berlin, Germany)1995
Receptors and G proteins as primary components of transmembrane signal transduction. Part 2. G proteins: structure and function.
Review in Journal of molecular medicine (Berlin, Germany), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 124 citations in OpenAlex.
- Analyses of Gnai3-iresGFP reporter mice reveal unknown GαScientific reports · 2021Article
- GαOncotarget · 2018Article
- Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex.Brain research · 2017Article
- AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.Oncogene · 2015Article
- Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide.British journal of pharmacology · 2011Article
- New vistas in GPCR 3D structure prediction.Journal of molecular modeling · 2010Article
- Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms.The Journal of pharmacology and experimental therapeutics · 2009Article
- G-protein signaling: back to the future.Cellular and molecular life sciences : CMLS · 2005Review
- Review
- Receptors couple to L-type calcium channels via distinct Go proteins in rat neuroendocrine cell lines.The Journal of physiology · 1997Article
- Effect of guanine nucleotides on [3H]glutamate binding and on adenylate cyclase activity in rat brain membranes.Neurochemical research · 1997Article
- Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain.The Biochemical journal · 1996Article
- Species- and tissue-dependent diversity of G-protein beta subunit phosphorylation: evidence for a cofactor.The Biochemical journal · 1996Article
- A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-beta.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.Basic research in cardiology · 1996Review
- Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function.Journal of molecular medicine (Berlin, Germany) · 1995Review
- Na+/H+ exchange in hypertension and in diabetes mellitus--facts and hypotheses.Basic research in cardiologyReview
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seven-transmembrane receptors signal through nucleotide-binding proteins (G proteins) into the cell. G proteins are membrane-associated proteins composed of three subunits termed alpha, beta and gamma, of which the G alpha subunit classifies the heterotrimer. So far, 23 different mammalian G alpha subunits are known, which are grouped in four subfamilies (Gs, Gi, Gq, G12) on the basis of their amino acid similarity. They carry an endogenous GTPase activity allowing reversible functional coupling between ligand-bound receptors and effectors such as enzymes and ion channels. In addition, five G beta and seven G gamma subunits have been identified which form tightly associated beta gamma heterodimers. Upon activation by a ligand-bound receptor the G protein dissociates into G alpha and G beta gamma, which both transmit signal by interacting with effectors. On the G protein level, specificity and selectivity of the incoming signal is accomplished by G protein trimers composed of distinct subunits. On the other hand, many receptors have been shown to activate different G proteins, thereby regulating diverse signal transduction pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.