ArticleThe Journal of experimental medicine1995
Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 96 citations in OpenAlex.
- Cancer and innate immune system interactions: translational potentials for cancer immunotherapy.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2012Review
- Complete elucidation of a minimal class I MHC natural killer cell receptor haplotype.Genes and immunity · 2005Article
- Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Immune functions encoded by the natural killer gene complex.Nature reviews. Immunology · 2003Review
- Genetic control of natural killing and in vivo tumor elimination by the Chok locus.The Journal of experimental medicine · 1998Article
- Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene.The Journal of experimental medicine · 1997Article
- Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in natural killer cell development.The Journal of experimental medicine · 1997Article
- Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.The Journal of experimental medicine · 1997Article
- The Ly-49D receptor activates murine natural killer cells.The Journal of experimental medicine · 1996Article
- Heterogeneity among Ly-49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns.The Journal of experimental medicine · 1996Article
- An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.The Journal of experimental medicine · 1996Article
- Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions.The Journal of experimental medicine · 1996Article
- Hybrid resistance and the Ly-49 family of natural killer cell receptors.The Journal of experimental medicine · 1995Review
- Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)The Journal of experimental medicine · 1995Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
5E6 is a cell surface molecule expressed on a subpopulation of murine natural killer (NK) cells that are involved in the specific rejection of H-2d or H-2f (hemopoietic histocompatibility determinant 2) bone marrow cell grafts. Here, we isolated and cloned the gene encoding 5E6 and determined the nucleotide sequence of the cDNA. 5E6 is nearly identical to Ly-49C; the deduced amino acid sequence reveals a polypeptide of 266 amino acids with a molecular weight of 31,284 that contains multiple cysteine residues to explain its disulfide-linked homodimer structure and five potential N-linked glycosylation sites. 5E6 is a type II integral membrane protein with an extracellular carbohydrate recognition domain characteristic of C-type (Ca(2+)-dependent) animal lectins. Chromosomal mapping indicates that 5E6 is located within the NK gene complex on chromosome 6. The sequence of 5E6 mRNA and the degree of glycosylation of 5E6 protein are under genetic control. Immunoprecipitation before removal of N-linked sugars reveals different size molecules. There are several nucleotide differences among BALB/c, B6, and NZB mRNAs; however, none of them would be expected to affect N-glycosylation. Of particular interest are two findings: (a) BALB/c, B6, and (BALB/c x B6)F1 5E6 reduced molecules are approximately 65, 54, and 54 kD, and (b) the cDNA sequence of (BALB/c x B6)F1 is identical to B6. Thus, there appears to be allelic exclusion of 5E6 expression that may be related to the ability of F1 hybrid mice to reject parental H-2d bone marrow cell grafts.
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