ArticleJournal of clinical pathology1995
Oncogene proteins and proliferation antigens in thymomas: increased expression of epidermal growth factor receptor and Ki67 antigen.
Article in Journal of clinical pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 45 citations in OpenAlex.
- Current Clinical Paradigm and Therapeutic Advancements in Thymic Malignancies: A Narrative Review.Cancers · 2025Review
- The Way Ahead: Lessons Learned from Decades of Cancer Research on Thymomas and Thymic Carcinomas.Cancers · 2024Article
- Non-Mutational Key Features in the Biology of Thymomas.Cancers · 2024Review
- Review
- KRAS, EGFR, PDGFR-α, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE).Diagnostic pathology · 2014Article
- Thymic malignancies: from clinical management to targeted therapies.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Review
- Glucocorticoids induce G1 cell cycle arrest in human neoplastic thymic epithelial cells.Journal of cancer research and clinical oncology · 2005Article
- Thymoma and thymic carcinoma: an update of the WHO Classification 2004.Surgery today · 2005Review
- Tyrosine kinase receptor expression in thymomas.Journal of cancer research and clinical oncology · 2004Article
- Ets-1 gene expression in patients with thymoma.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi · 2002Article
- High frequency of p53 protein expression in thymic carcinoma but not in thymoma.British journal of cancer · 1997Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
aimsTo examine thymomas for proteins encoded by oncogenes and to determine whether their presence correlates with tumour growth and associated myasthenia gravis.
methodsSections of 24 thymomas were incubated with anti-EGF receptor (EGF-R), anti-Ki67 antigen, anti-p53, and anti-bcl-2 antibodies, and then stained using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Cell suspensions and epithelial cell cultures from some of the tumours were also studied.
resultsWhereas EGF-R expression was not detected in any of the controls (but only in a 20 week old fetus), it was detected in neoplastic epithelial cells of all thymomas, and was most strongly expressed in metastases and in samples from donors with severe myasthenia gravis. Ki67 labelling was also increased, especially in the larger thymomas. Epithelial expression of both of these markers was confirmed in fresh cell suspensions and monolayer cultures from the five available cases. In contrast, p53 and bcl-2 were not detected in the neoplastic cells, but bcl-2 was present in the intermingling thymocytes.
conclusionsNeoplastic thymoma cells express EGF-R and Ki67, but there is no concomitant increase in the expression of p53 and bcl-2 proteins. Increased EGF-R expression may result in increased proliferation of neoplastic cells and also in myasthenia gravis. Measurement of EGF-R concentrations may be of prognostic value. The bcl-2 staining pattern in T lymphocytes illustrates the broad spectrum of maturational stages in thymoma lymphocytes.
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