ReviewJournal of bioenergetics and biomembranes1995
Effects of phosphorylation of P-glycoprotein on multidrug resistance.
Review in Journal of bioenergetics and biomembranes, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 63 citations in OpenAlex.
- The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer.Archives of medical science : AMS · 2020Article
- Study of Absorption Characteristics of the Total Saponins from Radix Ilicis Pubescentis in an In Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC).Molecules (Basel, Switzerland) · 2017Article
- Distinct conformational spectrum of homologous multidrug ABC transporters.Structure (London, England : 1993) · 2015Article
- Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?Drug metabolism and disposition: the biological fate of chemicals · 2014Review
- Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.Biochemistry · 2011Article
- Analysis of P-glycoprotein expression in purified parasite plasma membrane and food vacuole from Plasmodium falciparum.Parasitology research · 2006Article
- Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!The Journal of physiology · 2000Review
- Protein kinases and multidrug resistance.Cytotechnology · 1998Article
- Molecular analysis of the multidrug transporter, P-glycoprotein.Cytotechnology · 1998Article
- Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Regulation of organic anion transport in the liver.The Yale journal of biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells expressing elevated levels of the membrane phosphoprotein P-glycoprotein exhibit a multidrug resistance phenotype. Studies involving protein kinase activators and inhibitors have implied that covalent modification of P-glycoprotein by phosphorylation may modulate its biological activity as a multidrug transporter. Most of these reagents, however, have additional mechanisms of action and may alter drug accumulation within multidrug resistant cells independent of, or in addition to, their effects on the state of phosphorylation of P-glycoprotein. The protein kinase(s) responsible for P-glycoprotein phosphorylation has(ve) not been unambiguously identified, although several possible candidates have been suggested. Recent biochemical analyses demonstrate that the major sites of phosphorylation are clustered within the linker region that connects the two homologous halves of P-glycoprotein. Mutational analyses have been initiated to confirm this finding. Preliminary data obtained from phosphorylation- and dephosphorylation-defective mutants suggest that phosphorylation of P-glycoprotein is not essential to confer multidrug resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.