ArticleInflammation1995
Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase.
Article in Inflammation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06640309 (The Effect of Nicotinamide on the Clinical Outcome of Rheumatoid Arthritis Patients), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Nicotinamide on the Clinical Outcome of Rheumatoid Arthritis Patients
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- PARP1 as a novel therapeutic and diagnostic tool in autoimmune rheumatic diseases: a systematic literature review.Rheumatology international · 2026Pooled it
- A retrospective analysis of adverse drug reaction case reports for PARP inhibitors: a comparative study of olaparib and niraparib.Frontiers in pharmacology · 2026Pooled it
- Negative ion formation and fragmentation upon dissociative electron attachment to the nicotinamide molecule.RSC advances · 2021Article
- Review
- Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment.Biomolecules · 2020Review
- Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide.Metabolomics : Official journal of the Metabolomic Society · 2019Review
- Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity.Microbiology and molecular biology reviews : MMBR · 2019Review
- The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis.Mediators of inflammation · 2015Review
- PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell death.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities.British journal of pharmacology · 2014Review
- Association of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis.Human genome variation · 2014Article
- Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1.The American journal of pathology · 2013Article
- Safety and efficacy of nicotinamide in the management of hyperphosphatemia in patients on hemodialysis.Indian journal of nephrology · 2011Article
- The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.Rheumatology international · 2009Article
- Nitric oxide and peroxynitrite in health and disease.Physiological reviews · 2007Review
- Neutrophil apoptosis in autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2006Review
- Enhancing the inhibitory effect of nicotinamide upon collagen II induced arthritis in mice using N-acetylcysteine.Inflammation · 1999Article
- Enhancement of the effect of methotrexate on collagen II induced arthritis in mice by nicotinamide.Inflammation · 1998Article
- Review
- Priming of NADPH oxidase by tumor necrosis factor alpha in patients with inflammatory and autoimmune rheumatic diseases.Inflammation · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(ADPR) polymerase (PARP; EC 2.4.2.30) is a nuclear enzyme, which, when activated by oxygen- and nitrogen-radical-induced DNA strand breaks, transfers ADP ribose units to nuclear proteins and initiates apoptosis by depletion of cellular NAD and ATP pools. The present study investigates whether the oxidative stress-dependent activation of PARP plays a role in the etiopathogenesis of arthritis. The antiarthritic reactivity of the biogenic PARP inhibitor nicotinamide was tested in DBA/1 x B10A(4R) mice suffering from potassium peroxochromate-induced arthritis. Daily doses of 4 mmol/kg of NA suppressed the arthritis by 35% and inhibited the phagocytic generation of reactive oxygen species, which increases sixfold during the development of arthritis. The onset, progression, and remission of arthritis correlated positively to the phorbolester-activated respiratory burst of neutrophils and monocytes, and a dose-dependent inhibition of NADPH oxidase activity was determined with human phagocytes. Our data support the hypothesis that oxidative stress-induced alterations in cellular signal transduction pathways play a pivotal role in the development of arthritis, which can be suppressed by the simultaneous inhibition of poly(ADPR) polymerase and NADPH oxidase.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.