ArticleInflammation1995
Differential induction of stress proteins and functional effects of heat shock in human phagocytes.
Article in Inflammation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Cell type-specific variations in the induction of hsp70 in human leukocytes by feverlike whole body hyperthermia.Cell stress & chaperones · 2001Trial
- Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury.Cells · 2020Review
- Heat shock protein signaling in brain ischemia and injury.Neuroscience letters · 2020Review
- The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.Expert opinion on therapeutic targets · 2018Review
- HSP70 in human polymorphonuclear and mononuclear leukocytes: comparison of the protein content and transcriptional activity of HSPA genes.Cell stress & chaperones · 2017Article
- Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.Neuroscience · 2015Article
- ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age.Oncotarget · 2014Article
- The immune modulating properties of the heat shock proteins after brain injury.Anatomy & cell biology · 2013Article
- Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury.Inflammopharmacology · 2012Review
- Transpupillary thermotherapy for atypical central serous chorioretinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Low Power Laser Irradiation Stimulates the Proliferation of Adult Human Retinal Pigment Epithelial Cells in Culture.Cellular and molecular bioengineering · 2009Article
- Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70.Anesthesiology · 2008Review
- Heat-shocked monocytes are resistant to Staphylococcus aureus-induced apoptotic DNA fragmentation due to expression of HSP72.Infection and immunity · 1999Article
- Flow-mediated cell stress induction in adherent leukocytes is accompanied by modulation of morphology and phagocytic function.Medical & biological engineering & computing · 1999Article
- Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency.The Journal of clinical investigation · 1999Article
- Article
- Apoptosis of monocytes and prolonged survival of granulocytes as a result of phagocytosis of bacteria.Infection and immunity · 1996Article
- Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Phagocytosis of Pseudomonas aeruginosa fails to elicit heat shock protein expression in human monocytes.Inflammation · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induction of specific heat shock (HS) proteins (HSP) has been described as a response of human monocytes to phagocytosis, and HSP may play protective roles in infection and immunity. Here we compared the stress response in monocytes and polymorphonuclear neutrophils during exposure to the classical inducers of HSP, i.e., HS and cadmium. We also investigated the stress response in these two phagocytic cells after particulate (phagocytosis) and nonparticulate [f-Met-Leu-Phe (FMLP)] activation of the respiratory burst enzyme NADPH oxidase. HS and cadmium induced stress protein synthesis in both cell types. In contrast, phagocytosis induced HSP in monocytes only, while FMLP did so in neutrophils only. This differential regulation of stress proteins might relate to physiological and functional differences between monocytes and neutrophils. With respect to functional effects of HS, we examined, in human monocytes and in neutrophils, the effect of HS on NADPH oxidase-mediated O2- generation as well as on phagocytosis, bacterial killing, and superoxide dismutase (SOD) activity. In monocytes, as in neutrophils, NADPH oxidase activity was inhibited by HS, while thermotolerance prevented this inhibition. Phagocytosis and bacterial killing were unaltered by HS. SOD activity transiently increased in monocytes but decreased in neutrophils upon exposure to HS. These observations indicate differential induction of HSP in human phagocytes and differential regulation of phagocytes' functions by HS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.