ArticleThe EMBO journal1995
Splicing of cauliflower mosaic virus 35S RNA is essential for viral infectivity.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 82 citations in OpenAlex.
- Nuclear export of plant pararetrovirus mRNAs involves the TREX complex, two viral proteins and the highly structured 5' leader region.Nucleic acids research · 2021Article
- Cauliflower mosaic virus transactivator protein (TAV) can suppress nonsense-mediated decay by targeting VARICOSE, a scaffold protein of the decapping complex.Scientific reports · 2019Article
- Ribosome Shunting, Polycistronic Translation, and Evasion of Antiviral Defenses in Plant Pararetroviruses and Beyond.Frontiers in microbiology · 2018Review
- Setting Up Shop: The Formation and Function of the Viral Factories ofFrontiers in plant science · 2017Review
- Cauliflower mosaic virus Transcriptome Reveals a Complex Alternative Splicing Pattern.PloS one · 2015Article
- Reevaluation of the reliability and usefulness of the somatic homologous recombination reporter lines.The Plant cell · 2012Review
- Host cell processes to accomplish mechanical and non-circulative virus transmission.Protoplasma · 2012Review
- Article
- The ribosomal shunt translation strategy of cauliflower mosaic virus has evolved from ancient long terminal repeats.Journal of virology · 2006Article
- The open reading frame VI product of Cauliflower mosaic virus is a nucleocytoplasmic protein: its N terminus mediates its nuclear export and formation of electron-dense viroplasms.The Plant cell · 2005Article
- Dissection of cauliflower mosaic virus transactivator/viroplasmin reveals distinct essential functions in basic virus replication.Journal of virology · 2003Article
- Review
- Viral strategies of translation initiation: ribosomal shunt and reinitiation.Progress in nucleic acid research and molecular biology · 2002Review
- New ways of initiating translation in eukaryotes?Molecular and cellular biology · 2001Review
- Ribosome shunt is essential for infectivity of cauliflower mosaic virus.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Interaction of the cauliflower mosaic virus coat protein with the pregenomic RNA leader.Journal of virology · 2000Article
- In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA.The Journal of clinical investigation · 2000Article
- The AG dinucleotide terminating introns is important but not always required for pre-mRNA splicing in the maize endospermPlant physiology · 1999Article
- Forced evolution reveals the importance of short open reading frame A and secondary structure in the cauliflower mosaic virus 35S RNA leader.Journal of virology · 1998Article
- Rice tungro bacilliform virus open reading frames II and III are translated from polycistronic pregenomic RNA by leaky scanning.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A splicing event essential for the infectivity of a plant pararetrovirus has been characterized. Transient expression experiments using reporter constructs revealed a splice donor site in the leader sequence of the cauliflower mosaic virus (CaMV) 35S RNA and three additional splice donor sites within open reading frame (ORF) I. All four donors use the same splice acceptor within ORF II. Splicing between the leader and ORF II produces an mRNA from which ORF III and, in the presence of the CaMV translational transactivator, ORF IV can be translated efficiently. The other three splicing events produce RNAs encoding ORF I-II in-frame fusions. All four spliced CaMV RNAs were detected in CaMV-infected plants. Virus mutants in which the splice acceptor site in ORF II is inactivated are not infectious, indicating that splicing plays an essential role in the CaMV life cycle. The results presented here suggest a model for viral gene expression in which RNA splicing is required to provide appropriate substrate mRNAs for the specialized translation mechanisms of CaMV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.