ArticleThe EMBO journal1995
The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 118 citations in OpenAlex.
- Interaction Between Transcription Factor EhPC4 and Polyadenylation Factor EhCFIm25 inMicroorganisms · 2026Article
- Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis.Cell communication and signaling : CCS · 2025Article
- The single-stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular Mechanisms of Functional Modulation of Transcriptional Coactivator PC4 via Phosphorylation on Its Intrinsically Disordered Region.ACS omega · 2023Article
- The Catalytic Subunit ofInternational journal of molecular sciences · 2022Article
- Article
- Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors.Nature communications · 2021Article
- Genome-Wide Association Study RevealsFrontiers in genetics · 2021Article
- Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression.BMC molecular biology · 2018Article
- A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4.The Journal of biological chemistry · 2017Article
- Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis.Nucleic acids research · 2017Article
- MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.Oncogene · 2016Article
- PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.Oncogene · 2016Article
- The Sub1 nuclear protein protects DNA from oxidative damage.Molecular and cellular biochemistry · 2016Article
- The intrinsic disorder alphabet. III. Dual personality of serine.Intrinsically disordered proteins · 2015Review
- Identification of the ssDNA-binding protein of bacteriophage T5: Implications for T5 replication.Bacteriophage · 2013Article
- Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repair.PloS one · 2013Article
- Sub1 associates with Spt5 and influences RNA polymerase II transcription elongation rate.Molecular biology of the cell · 2012Article
- Peptide-protein interactions suggest that acetylation of lysines 381 and 382 of p53 is important for positive coactivator 4-p53 interaction.The Journal of biological chemistry · 2011Article
- Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed the mechanisms underlying stimulation of transcription by the activator GAL4-AH and the recombinant coactivator p15 (PC4). We show that p15 binds to both double-stranded and single-stranded DNA. Analyses of deletion mutants correlates binding to double-stranded DNA with the ability to mediate activator-dependent transcription. Consistent with this finding, phosphorylation of p15 by casein kinase II inhibits binding to double-stranded DNA and the activity of p15. The functional characterization suggests interactions of p15 with both DNA and components of the TFIID complex. GAL4-AH functions in concert with p15 during formation of TFIIA-TFIID-promoter (DA) complexes, as concluded from order-of-addition experiments. At limiting TFIID concentrations, the number of DA complexes is enhanced. The activator also stimulates transcription moderately after DA complex formation, independently of the concentrations of general transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.