ArticleThe EMBO journal1995
Involvement of SOX proteins in lens-specific activation of crystallin genes.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 236 citations in OpenAlex.
- Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm.Results and problems in cell differentiation · 2024Article
- Insights into Bone Morphogenetic Protein-(BMP-) Signaling in Ocular Lens Biology and Pathology.Cells · 2021Review
- The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development.Human molecular genetics · 2020Article
- Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor.Nucleic acids research · 2018Article
- DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors.Nucleic acids research · 2015Article
- Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner.Developmental biology · 2015Article
- Sox2 transcription network acts as a molecular switch to regulate properties of neural stem cells.World journal of stem cells · 2014Review
- The role of a lens survival pathway including sox2 and αA-crystallin in the evolution of cavefish eye degeneration.EvoDevo · 2014Article
- SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.PLoS genetics · 2013Article
- Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses.Human genomics · 2012Article
- Xmab21l3 mediates dorsoventral patterning in Xenopus laevis.Mechanisms of development · 2012Article
- Lens development depends on a pair of highly conserved Sox21 regulatory elements.Developmental biology · 2012Article
- A homolog of Subtilisin-like Proprotein Convertase 7 is essential to anterior neural development in Xenopus.PloS one · 2012Article
- Fishing pluripotency mechanisms in vivo.International journal of biological sciences · 2011Review
- The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium.Molecular vision · 2010Article
- Article
- Molecular and cellular aspects of amphibian lens regeneration.Progress in retinal and eye research · 2010Article
- Examination of SOX2 in variable ocular conditions identifies a recurrent deletion in microphthalmia and lack of mutations in other phenotypes.Molecular vision · 2010Article
- Pax6 is essential for lens fiber cell differentiation.Development (Cambridge, England) · 2009Article
- Evolution of non-coding regulatory sequences involved in the developmental process: reflection of differential employment of paralogous genes as highlighted by Sox2 and group B1 Sox genes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2009Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the mechanism of delta 1-crystallin gene activation, which occurs early in lens cell differentiation, and have previously shown that an essential element of the delta 1-crystallin enhancer is bound by a group of nuclear factors, delta EF2, among which delta EF2a is highly enriched in lens cells. In this report we show that the cDNA of delta EF2a codes for the chicken SOX-2 protein (cSOX-2), which is structurally related to the sex-determining factor SRY. Sox-2 is expressed at high levels in the early developing lens in both chicken and mouse embryos. Overexpression of delta EF2a/cSOX-2 increased delta 1-crystallin enhancer activity to a plateau in lens cells, but not in fibroblasts, consistent with the previously drawn conclusion that delta EF2a activates transcription only in concert with another factor present in the lens. This result supports the model that SOX proteins act as architectural components in the activating complex formed on an enhancer, as indicated for another HMG domain protein, lymphoid enhancer binding factor 1 (LEF-1). We also show that SOX protein binding is essential for lens-specific promoter activity of the mouse gamma F-crystallin gene. This work is the first to show delta- and gamma-crystallin genes as examples of direct regulatory targets of SOX proteins and provides evidence that diversified crystallin genes are regulated, at least partly, by a common mechanism.
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