Evidence map›Paper›PMID 7625998›Full record

ArticleThe Biochemical journal1995

Lack of association of G-protein beta 2- and gamma 2-subunit N-terminal fragments provides evidence against the coiled-coil model of subunit-beta gamma assembly.

E P Marin, R R Neubig

Abstract read
In one paragraph

Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

E P MarinDepartment of Pharmacology, University of Michigan, Ann Arbor 48109-0632, USA.
R R Neubig

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
STRUCTURAL BASIS OF RECEPTOR/G PROTEIN FUNCTIONR01HL046417 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEUBIG, RICHARD R · 1992 to 2004
$1.3M
NHLBI NIH HHS HLGM 46417NIGMS NIH HHS GM 07863NIGMS NIH HHS GM 39561
6 · The paper itself

Abstract

The association between peptides from bovine G-protein beta 2- and gamma 2-subunits was studied by CD spectroscopy and cross-linking. Both peptides had approximately 25% stable alpha-helical structure at 25 degrees C, but there was no increase on mixing subunits as expected for coiled-coil formation. Also, disulphide cross-linking gave more beta 2 beta 2 homodimer than beta 2 gamma 2 heterodimer. These data do not support the proposed N-terminal coiled-coil model of beta gamma-subunit association.

Indexed as

Amino Acid SequenceAnimalsCattleChromatography, High Pressure LiquidCircular DichroismCross-Linking ReagentsDisulfidesGTP-Binding ProteinsMass SpectrometryMolecular Sequence DataPeptide FragmentsProtein ConformationCross-Linking ReagentsDisulfidesGTP-Binding ProteinsPeptide Fragments

Identifiers

PMID7625998
PMCPMC1135741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.