ArticleProceedings of the National Academy of Sciences of the United States of America1995
Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Crosstalk collapse: mitochondria-centric organelle network disruption in ovarian aging.Cell communication and signaling : CCS · 2026Review
- Multi-Omics Analysis Provides New Insights into the Interplay Between Gut Microbiota, Fatty Acid Metabolism, and Immune Response in Cultured and WildMicroorganisms · 2025Article
- Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Targeting the core program of metastasis with a novel drug combination.Cancer medicine · 2024Article
- Article
- Peroxisome Metabolism in Cancer.Cells · 2020Review
- SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.EMBO reports · 2018Article
- Redox interplay between mitochondria and peroxisomes.Frontiers in cell and developmental biology · 2015Review
- Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- The Role of PPARs in Cancer.PPAR research · 2008Article
- Cytochrome P450 and xenobiotic receptor humanized mice.Annual review of pharmacology and toxicology · 2006Review
- Mammalian peroxisomes and reactive oxygen species.Histochemistry and cell biology · 2004Review
- Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensing.The American journal of pathology · 2004Article
- Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease.Comparative hepatology · 2003Article
- Tumorigenic conversion of a rat urothelial cell line by human polymorphonuclear leukocytes activated by lipopolysaccharide.Japanese journal of cancer research : Gann · 1999Article
- Activation of flavin-containing oxidases underlies light-induced production of H2O2 in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma.Gene expression · 1996Article
- Functional expression and peroxisomal targeting of rat urate oxidase in monkey kidney cells.Gene expression · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Peroxisome proliferators induce qualitatively predictable pleiotropic responses, including development of hepatocellular carcinomas in rats and mice despite the inability of these compounds to interact with and damage DNA directly. In view of the nongenotoxic nature of peroxisome proliferators, it has been postulated that hepatocarcinogenesis by this class of chemicals is due to a receptor-mediated process leading to transcriptional activation of H2O2-generating peroxisomal fatty acyl-CoA oxidase (ACOX) in liver. To test this hypothesis, we overexpressed rat ACOX in African green monkey kidney cells (CV-1 cells) under control of the cytomegalovirus promoter. A stably transfected CV-1 cell line overexpressing rat ACOX, designated CV-ACOX4, when exposed to a fatty acid substrate (150 microM linoleic acid) for 2-6 weeks, formed transformed foci, grew efficiently in soft agar, and developed adenocarcinomas when transplanted into nude mice. These findings indicate that sustained overexpression of H2O2-generating ACOX causes cell transformation and provide further support for the role of peroxisome proliferation in hepatocarcinogenesis induced by peroxisome proliferators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.