ArticleProceedings of the National Academy of Sciences of the United States of America1995
Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Nitric Oxide Activates β-Cell Glucokinase by Promoting Formation of the "Glucose-Activated" State.Biochemistry · 2018Article
- Efficacy and immunogenicity of single-dose AdVAV intranasal anthrax vaccine compared to anthrax vaccine absorbed in an aerosolized spore rabbit challenge model.Clinical and vaccine immunology : CVI · 2015Article
- Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic beta-cells to correct diabetes in allogeneic mice.Gene therapy · 2009Article
- Adenovirus RIDalphabeta complex inhibits lipopolysaccharide signaling without altering TLR4 cell surface expression.Journal of virology · 2006Article
- Article
- Mechanism for removal of tumor necrosis factor receptor 1 from the cell surface by the adenovirus RIDalpha/beta complex.Journal of virology · 2005Article
- Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K.Journal of virology · 2005Article
- Inhibition of tumor necrosis factor (TNF) signal transduction by the adenovirus group C RID complex involves downregulation of surface levels of TNF receptor 1.Journal of virology · 2004Article
- Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization.Nucleic acids research · 2004Article
- Inhibition of chemokine expression by adenovirus early region three (E3) genes.Journal of virology · 2002Article
- Inhibition of tumor necrosis factor alpha-induced NF-kappa B activation by the adenovirus E3-10.4/14.5K complex.Journal of virology · 2002Article
- Current research on respiratory viral infections: Third International Symposium.Antiviral research · 2001Review
- Xenogeneic islet re-transplantation in mice triggers an accelerated, species-specific rejection.Immunology · 2000Article
- Review
- A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.The Journal of experimental medicine · 1999Article
- Article
- Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.The Journal of clinical investigation · 1998Article
- The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Surrogate beta cells.Diabetologia · 1997Article
- Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adenovirus (Ad) early region 3 (E3) genes code for at least four proteins that inhibit the host immune responses mediated by cytotoxic T lymphocytes and tumor necrosis factor alpha. To evaluate the potential use of these immunoregulatory viral functions in facilitating allogeneic cell transplantation, the Ad E3 genes were expressed in pancreatic beta cells in transgenic mice under control of the rat insulin II promoter. Transgenic H-2b/d (C57BL/6 x BALB/c) islets, expressing the Ad E3 genes, remained viable for at least 94 days after transplantation under the kidney capsule of BALB/c (H-2d) recipients. Nontransgenic H-2b/d control islets were rejected as anticipated between 14 and 28 days. Histological analysis of the transplanted transgenic islets revealed normal architecture. Immunohistochemical studies with antisera to islet hormones revealed the presence of both beta and non-beta islet cells, suggesting a propagation of the immunosuppressive effect of Ad proteins from beta cells to other islet cells. The use of viral genes, which have evolved to regulate virus-host interactions, to immunosupress the anti-genicity of donor transplant tissue suggests additional ways for prolonging allograft survival. In addition, these findings have implications for designing Ad vectors for gene therapy.
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