ArticleProceedings of the National Academy of Sciences of the United States of America1995
Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine.Infection and immunity · 2005Trial
- Expression of a leptospiral leucine-rich repeat protein using a food-grade vector in3 Biotech · 2019Article
- Vaccine Approaches To Protect against Group A Streptococcal Pharyngitis.Microbiology spectrum · 2019Review
- Intracellular delivery of HA1 subunit antigen through attenuated Salmonella Gallinarum act as a bivalent vaccine against fowl typhoid and low pathogenic H5N3 virus.Veterinary research · 2017Article
- Lactic acid bacteria - promising vaccine vectors: possibilities, limitations, doubts.Journal of applied microbiology · 2017Review
- Immunogenicity of a Bivalent Adjuvanted Glycoconjugate Vaccine againstFrontiers in immunology · 2017Article
- The Application of Magnetic Bead Selection to Investigate Interactions between the Oral Microbiota and Salivary Immunoglobulins.PloS one · 2016Article
- A novel live vector group A streptococcal emm type 9 vaccine delivered intranasally protects mice against challenge infection with emm type 9 group A streptococci.Clinical and vaccine immunology : CVI · 2014Article
- Intranasal vaccination with the recombinant Listeria monocytogenes ΔactA prfA* mutant elicits robust systemic and pulmonary cellular responses and secretory mucosal IgA.Clinical and vaccine immunology : CVI · 2011Article
- Anti-group A streptococcal vaccine epitope: structure, stability, and its ability to interact with HLA class II molecules.The Journal of biological chemistry · 2011Article
- Novel Sample Preparation for Mass Spectral Analysis of Complex Biological Samples.Current proteomics · 2010Article
- Primary activation of antigen-specific naive CD4+ and CD8+ T cells following intranasal vaccination with recombinant bacteria.Infection and immunity · 2008Article
- Engineering of a human vaginal Lactobacillus strain for surface expression of two-domain CD4 molecules.Applied and environmental microbiology · 2008Article
- Expression of a functional single-chain variable-fragment antibody against complement receptor 1 in Streptococcus gordonii.Clinical and vaccine immunology : CVI · 2008Article
- Host-derived pentapeptide affecting adhesion, proliferation, and local pH in biofilm communities composed of Streptococcus and Actinomyces species.Infection and immunity · 2006Article
- Stimulation of human monocytes with the gram-positive vaccine vector Streptococcus gordonii.Clinical and vaccine immunology : CVI · 2006Article
- Live bacterial vaccines--a review and identification of potential hazards.Microbial cell factories · 2006Article
- In vivo activation of naive CD4+ T cells in nasal mucosa-associated lymphoid tissue following intranasal immunization with recombinant Streptococcus gordonii.Infection and immunity · 2006Article
- Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism.Advanced drug delivery reviews · 2005Review
- Expression and immunogenicity of a recombinant diphtheria toxin fragment A in Streptococcus gordonii.Applied and environmental microbiology · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To circumvent the need to engineer pathogenic microorganisms as live vaccine-delivery vehicles, a system was developed which allowed for the stable expression of a wide range of protein antigens on the surface of Gram-positive commensal bacteria. The human oral commensal Streptococcus gordonii was engineered to surface express a 204-amino acid allergen from hornet venom (Ag5.2) as a fusion with the anchor region of the M6 protein of Streptococcus pyogenes. The immunogenicity of the M6-Ag5.2 fusion protein was assessed in mice inoculated orally and intranasally with a single dose of recombinant bacteria, resulting in the colonization of the oral/pharyngeal mucosa for 10-11 weeks. A significant increase of Ag5.2-specific IgA with relation to the total IgA was detected in saliva and lung lavages when compared with mice colonized with wild-type S. gordonii. A systemic IgG response to Ag5.2 was also induced after oral colonization. Thus, recombinant Gram-positive commensal bacteria may be a safe and effective way of inducing a local and systemic immune response.
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