ArticleMolecular and cellular biology1995
A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 82 citations in OpenAlex.
- Mechanisms of Wnt signaling and control.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.Scientific reports · 2016Article
- Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.Genes & diseases · 2016Article
- WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.The New England journal of medicine · 2013Article
- The importance of Wnt signaling in cardiovascular development.Pediatric cardiology · 2010Review
- Article
- Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.Oncogene · 2004Article
- Identification of Wnt responsive genes using a murine mammary epithelial cell line model system.BMC developmental biology · 2004Article
- Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation.Oncogene · 2003Article
- A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.Molecular and cellular biology · 2003Article
- Wnt signaling and pulmonary fibrosis.The American journal of pathology · 2003Review
- Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.The Journal of cell biology · 2002Article
- Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription.The Journal of cell biology · 2001Article
- Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene.Molecular and cellular biology · 2001Article
- Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex.The Journal of cell biology · 2000Article
- Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Axin prevents Wnt-3a-induced accumulation of beta-catenin.Oncogene · 1999Article
- Chimeric Wnt proteins define the amino-terminus of Wnt-1 as a transformation-specific determinant.Oncogene · 1999Article
- Signal transduction by the Wnt family of ligands.The Biochemical journal · 1998Review
- High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer.British journal of cancer · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The proto-oncogene Wnt-1 plays an essential role in fetal brain development and causes hyperplasia and tumorigenesis when activated ectopically in the mouse mammary gland. When expressed in certain mammary epithelial cell lines, the gene causes morphological transformation and excess cell proliferation at confluence. Like other members of the mammalian Wnt family, Wnt-1 encodes secretory glycoproteins which have been detected in association with the extracellular matrix or cell surface but which have not previously been found in a soluble or biologically active form. We show here that conditioned medium harvested from a mammary cell line expressing Wnt-1 contains soluble Wnt-1 protein and induces mitogenesis and transformation of mammary target cells. By immunodepletion of medium containing epitope-tagged Wnt-1, we show that at least 60% of this activity is specifically dependent on Wnt-1 protein. These results provide the first demonstration that a mammalian Wnt protein can act as a diffusible extracellular signaling factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.