ArticleMolecular and cellular biology1995
Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- MEOX2: a homeobox transcription factor with multifaceted biological functions and broad disease associations.Frontiers in cell and developmental biology · 2026Review
- Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.American journal of translational research · 2016Article
- Mef2d acts upstream of muscle identity genes and couples lateral myogenesis to dermomyotome formation in Xenopus laevis.PloS one · 2012Article
- Article
- Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.Molecular oncology · 2007Article
- Inhibition of the cyclin D1/E2F pathway by PCA-4230, a potent repressor of cellular proliferation.British journal of pharmacology · 2001Article
- Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries.Gene therapy · 2000Article
- GATA-dependent recruitment of MEF2 proteins to target promoters.The EMBO journal · 2000Article
- Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor.The Journal of clinical investigation · 1999Article
- Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter.Molecular and cellular biology · 1999Article
- Role of c-fos and E2F in the induction of cyclin A transcription and vascular smooth muscle cell proliferation.The Journal of clinical investigation · 1998Article
- Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery.The Journal of clinical investigation · 1997Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Homeobox-containing genes play an essential role in basic processes during embryogenesis and development, but little is known about the regulation of their expression. To elucidate regulatory networks that govern homeobox gene expression, we defined the core promoter of the mouse Gax homeobox gene and characterized its interactions with cellular proteins. Transient transfection experiments revealed Gax promoter activity in several cell types. Deletion analysis defined a 138-bp minimal promoter fragment between positions -125 and +13 relative to the transcription initiation site. Mutagenesis and protein-DNA binding assays suggested that at least three positive factors interact with this fragment and are required for transcriptional activity. One of these factors, HRF-1, recognizes a cis element consisting of an inverted palindromic motif. A second factor is Sp1, that binds to a G/C-rich element. The third is the MADS box factor referred to as MEF2 or RSRF. Mutations in the MEF2/RSRF site had the greatest effect on transcription in cell types that expressed the highest levels of endogenous MEF2 activity. Conversely, overexpression of MEF2A transactivated the Gax promoter more efficiently in cells lacking endogenous MEF2. These data provide evidence for a direct transcriptional link between members of the MADS and homeobox families of transcription factors.
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