ArticleMolecular and cellular biology1995
Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 142 citations in OpenAlex.
- ChIP-exo and CRISPRi/a illuminate the role of Pdr1 and Yap1 in acetic acid tolerance inApplied and environmental microbiology · 2025Article
- Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast.International journal of molecular sciences · 2024Review
- Activity of the pleiotropic drug resistance transcription factors Pdr1p and Pdr3p is modulated by binding site flanking sequences.FEBS letters · 2024Article
- De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts.Nature communications · 2022Article
- SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes.Nature communications · 2022Article
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- RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in ρBMC microbiology · 2021Article
- Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility ofFrontiers in microbiology · 2020Article
- Unveiling the transcriptional control of pleiotropic drug resistance in Saccharomyces cerevisiae: Contributions of André Goffeau and his group.Yeast (Chichester, England) · 2019Review
- Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance.Current genetics · 2019Review
- Importance of Proteasome Gene Expression during Model Dough Fermentation after Preservation of Baker's Yeast Cells by Freezing.Applied and environmental microbiology · 2018Article
- Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor.Molecular microbiology · 2018Article
- Phytohormone sensing in the biotrophic fungus Ustilago maydis - the dual role of the transcription factor Rss1.Molecular microbiology · 2016Article
- Activation of the mitochondrial signaling pathway in response to organic solvent stress in yeast.Current genetics · 2015Article
- Activation of signaling pathways related to cell wall integrity and multidrug resistance by organic solvent in Saccharomyces cerevisiae.Current genetics · 2014Article
- Coherent feedforward transcriptional regulatory motifs enhance drug resistance.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- Yeast ABC proteins involved in multidrug resistance.Cellular & molecular biology letters · 2014Review
- Multidrug resistance in fungi: regulation of transporter-encoding gene expression.Frontiers in physiology · 2014Review
- Antifungal resistance and new strategies to control fungal infections.International journal of microbiology · 2012Article
- Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Simultaneous resistance to an array of drugs with different cytotoxic activities is a property of Saccharomyces cerevisiae, in which the protein Pdr3p has recently been shown to play a role as a transcriptional regulator. We provide evidence that the yeast PDR3 gene, which encodes a zinc finger transcription factor implicated in certain drug resistance phenomena, is under positive autoregulation by Pdr3p. DNase I footprinting analyses using bacterially expressed Pdr3p showed specific recognition by this protein of at least two upstream activating sequences in the PDR3 promoter. The use of lacZ reporter constructs, a mutational analysis of the upstream activating sequences, as well as band shift experiments enabled the identification of two 5'TC CGCGGA3' sequence motifs in the PDR3 gene as consensus elements for the binding of Pdr3p. Several similar sequence motifs can be found in the promoter of PDR5, a gene encoding an ATP-dependent drug pump whose Pdr3p-induced overexpression is responsible for drug resistance phenomena. Recently one of these sequence elements was shown to be the target of Pdr3p to elevate the level of PDR5 transcription. Finally, we provide evidence in the absence of PDR1 for a PDR3-controlled transcriptional induction of the drug pump by cycloheximide and propose a model for the mechanism governing the transcriptional autoregulation of Pdr3p.
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