ArticleMolecular and cellular biology1995
Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 223 citations in OpenAlex.
- Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax.PLoS genetics · 2025Article
- Multimodal Hox5 activity generates motor neuron diversity.Communications biology · 2024Article
- Integrative analysis reveals novel insights into juvenile idiopathic arthritis pathogenesis and shared molecular pathways with associated traits.Frontiers in genetics · 2024Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
- A Computer-Based Methodology to Design Non-Standard Peptides Potentially Able to Prevent HOX-PBX1-Associated Cancer Diseases.International journal of molecular sciences · 2021Article
- Chromatin accessibility plays a key role in selective targeting of Hox proteins.Genome biology · 2019Article
- Review
- A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.Scientific reports · 2016Article
- Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.Neuron · 2015Article
- Control of brain patterning by Engrailed paracrine transfer: a new function of the Pbx interaction domain.Development (Cambridge, England) · 2015Article
- HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia.Oncotarget · 2013Article
- Hoxb8 regulates expression of microRNAs to control cell death and differentiation.Cell death and differentiation · 2013Article
- Review
- Protein interactions of the transcription factor Hoxa1.BMC developmental biology · 2012Article
- Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.Journal of Zhejiang University. Science. B · 2012Article
- Cardiovascular defects in a mouse model of HOXA1 syndrome.Human molecular genetics · 2012Article
- Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors.PLoS biology · 2012Article
- Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.PloS one · 2012Article
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Article
19 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeoprotein products of the Hox/HOM gene family pattern the animal embryo through the transcriptional regulation of target genes. We have previously shown that the labial group protein HOXA-1 has intrinsically weak DNA-binding activity due to residues in the N-terminal arm of its homeodomain (M. L. Phelan, R. Sadoul, and M. S. Featherstone, Mol. Cell. Biol. 14:5066-5075, 1994). This observation, among others, suggests that HOX and HOM proteins require cofactors for stable interactions with DNA. We have demonstrated that a putative HOX cofactor, PBX1A, participates in cooperative DNA binding with HOXA-1 and the Deformed group protein HOXD-4. Three Abdominal-B class HOX proteins failed to cooperate with PBX1A. We mapped the interacting domain of HOXD-4 to the YPWMK pentapeptide motif, a conserved sequence found N terminal to the homeodomain of HOXA-1 and many other homeoproteins but absent from the Abdominal-B class. The naturally occurring fusion of the transcriptional activation domain of E2A with PBX1 creates an oncoprotein implicated in human pre-B-cell leukemias (M. P. Kamps, C. Murre, X.-H. Sun, and D. Baltimore, Cell 60:547-555, 1990; J. Nourse, J. D. Mellentin, N. Galili, J. Wilkinson, E. Starbridge, S. D. Smith, and M. L. Cleary, Cell 60:535-545, 1990). A pentapeptide mutation that abolished cooperative interaction with PBX1A in vitro also abrogated synergistic transcriptional activation with the E2A/PBX oncoprotein. The direct contact of PBX family members by the HOX pentapeptide is likely to play an important role in developmental and oncogenic processes.
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