ArticleMolecular and cellular biochemistry1995
Stretch affects phenotype and proliferation of vascular smooth muscle cells.
Article in Molecular and cellular biochemistry, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 204 citations in OpenAlex.
- Vascular mechanical forces and vascular diseases.Journal of advanced research · 2026Review
- Wall Shear Stress Alteration: a Local Risk Factor of Atherosclerosis.Current atherosclerosis reports · 2022Review
- The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency.Research (Washington, D.C.) · 2022Article
- Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls.International journal for numerical methods in biomedical engineering · 2020Article
- 3D bioprinting of vascular conduits for pediatric congenital heart repairs.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Tubuloids derived from human adult kidney and urine for personalized disease modeling.Nature biotechnology · 2019Article
- Thermosensitive and Highly Flexible Hydrogels Capable of Stimulating Cardiac Differentiation of Cardiosphere-Derived Cells under Static and Dynamic Mechanical Training Conditions.ACS applied materials & interfaces · 2016Article
- Magnitude-dependent proliferation and contractility modulation of human bladder smooth muscle cells under physiological stretch.World journal of urology · 2015Article
- The platelet and the biophysical microenvironment: lessons from cellular mechanics.Thrombosis research · 2014Review
- A novel system for studying mechanical strain waveform-dependent responses in vascular smooth muscle cells.Lab on a chip · 2013Article
- Improved recellularization of ex vivo vascular scaffolds using directed transport gradients to modulate ECM remodeling.Biotechnology and bioengineering · 2013Article
- The effect of pulsatile loading and scaffold structure for the generation of a medial equivalent tissue engineered vascular graft.BioResearch open access · 2013Article
- Mechanical regulation of epigenetics in vascular biology and pathobiology.Journal of cellular and molecular medicine · 2013Review
- Comparison of vascular smooth muscle cells in canine great vessels.BMC veterinary research · 2013Article
- Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion.PLoS pathogens · 2011Article
- Article
- Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering.Tissue engineering. Part B, Reviews · 2010Review
- Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.Journal of vascular research · 2010Review
- Cyclic stretch, reactive oxygen species, and vascular remodeling.Antioxidants & redox signaling · 2009Review
- Neointimal hyperplasia associated with synthetic hemodialysis grafts.Kidney international · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exertion of periodic dynamic strain on the arterial wall is hypothesized to be relevant to smooth muscle cell morphology and function. This study has investigated the effect of cyclic mechanical stretching on rabbit aortic smooth muscle cell proliferation and expression of contractile phenotype protein markers. Cells were cultured on flexible-bottomed dishes and cyclic stretch was applied (frequency 30 cycles/min, 15% elongation) using a Flexercell Strain unit. Cyclic stretch potentiated smooth muscle cell proliferation in serum-activated cultures but not in cultures maintained in 0.5% fetal calf serum. Stretching induced a serum-independent increase of h-caldesmon expression and this effect was reversible following termination of mechanical stimulation. Strain was without effect on smooth muscle myosin or calponin expression. In cells grown on laminin stretch-induced h-caldesmon expression was more prominent than in cells cultured on collagen types I and IV, poly-L-lysine and gelatin. These data suggest that cyclic mechanical stimulation possesses dual effect on vascular smooth muscle cell phenotype characteristics since it: 1) potentiates proliferation, an attribute of a dedifferentiated phenotype; and 2) increases expression of h-caldesmon considered a marker of a differentiated smooth muscle cell state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.