ArticleThe Journal of physiology1995
Characterization of single potassium channels in mouse pancreatic acinar cells.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- CO2-dependent opening of an inwardly rectifying K+ channel.Pflugers Archiv : European journal of physiology · 2011Article
- Delayed expression of large conductance K+ channels reshaping agonist-induced currents in mouse pancreatic acinar cells.The Journal of physiology · 2005Article
- Characterization of cell volume-sensitive chloride currents in freshly prepared and cultured pancreatic acinar cells from early postnatal rats.The Journal of physiology · 1998Article
- Inwardly rectifying, voltage-dependent and resting potassium currents in rat pancreatic acinar cells in primary culture.The Journal of physiology · 1997Article
- Ca2+ regulated K+ and non-selective cation channels in the basolateral membrane of rat colonic crypt base cells.Pflugers Archiv : European journal of physiology · 1996Article
- Different time courses of GTP[gamma-S]-induced exocytosis and current oscillations in isolated mouse pancreatic acinar cells.Pflugers Archiv : European journal of physiology · 1996Article
- The membrane transporters regulating epithelial NaCl secretion.Pflugers Archiv : European journal of physiology · 1996Review
- The cAMP-regulated and 293B-inhibited K+ conductance of rat colonic crypt base cells.Pflugers Archiv : European journal of physiology · 1996Article
- Whole-cell conductive properties of rat pancreatic acini.Pflugers Archiv : European journal of physiology · 1996Article
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2 authors.
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Abstract
1. Single K(+)-selective channels with a conductance of about 48 pS (pipette, 145 mM KCl; bath, 140 mM NaCl + 4.7 mM KCl) were recorded in the patch-clamp whole-cell configuration in isolated mouse pancreatic acinar cells. 2. Neither application of the secretagogues acetylcholine (second messenger, inositol 1,4,5-trisphosphate) or secretin (second messenger, cAMP), nor addition of the catalytic subunit of protein kinase A to the pipette solution changed the activity of the 48 pS K+ channel. 3. Intracellular acidification with sodium propionate (20 mM) diminished activity of the 48 pS channel, whereas channel open probability was increased by cytosolic alkalization with 20 mM NH4Cl. 4. BaCl2 (5 mM), TEA (10 mM) or apamin (1 microM) added to the bath solution had no obvious effect on the kinetics of the 48 pS channel. Similarly, glibenclamide and diazoxide failed to influence the channel activity. 5. When extracellular NaCl was replaced by KCl, whole-cell recordings revealed an inwardly rectifying K+ current carried by a 17 pS K+ channel. 6. The inwardly rectifying K+ current was not pH dependent and could largely be blocked by Ba2+ but not by TEA. 7. Since the 48 pS K+ channel is neither Ca2+ nor cAMP regulated, we suggest that this channel could play a role in the maintenance of the negative cell resting potential.
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