ArticleThe Journal of physiology1995
Release of Ca2+ by noradrenaline and ATP from the same Ca2+ store sensitive to both InsP3 and Ca2+ in rat portal vein myocytes.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris.Investigative ophthalmology & visual science · 2020Article
- Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta.Acta pharmacologica Sinica · 2016Article
- Inositol trisphosphate receptors in smooth muscle cells.American journal of physiology. Heart and circulatory physiology · 2012Review
- Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia.Respiratory physiology & neurobiology · 2010Review
- Inhibition of cerebral vasoconstriction by dantrolene and nimodipine.Neurocritical care · 2009Article
- Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells.Pflugers Archiv : European journal of physiology · 2007Article
- Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells.The Journal of general physiology · 2005Article
- Crosstalk between ryanodine receptors and IP(3) receptors as a factor shaping spontaneous Ca(2+)-release events in rabbit portal vein myocytes.The Journal of physiology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by noradrenaline (NA) and ATP were investigated using indo-1 microspectrofluorimetry in single smooth muscle cells of rat portal vein. 2. Activation of P2x-purinoceptors by ATP (10 microM) increased [Ca2+]i from 92 +/- 7 nM (n = 18) to 557 +/- 30 nM (n = 11). In the presence of NA (10 microM), the ATP-induced rise in [Ca2+]i was reduced to 23.6 +/- 1.5% (n = 7) of the control response (in the absence of NA). 3. Tetracaine (10 microM to 2 mM) inhibited in a concentration-dependent manner the Ca(2+)-induced Ca2+ release (CICR) evoked by 5 mM caffeine. In the presence of 1 mM tetracaine, the rise in [Ca2+]i induced by ATP (10(-8)-10(-4) M) was strongly inhibited. A tetracaine-resistant rise in [Ca2+]i, corresponding to 26.4 +/- 2.3% (n = 14) of control values, was recorded in response to 10 microM ATP. 4. The amplitude of the NA-induced [Ca2+]i rise depended on NA concentrations (10(-8)-10(-5) M) and was not modified by tetracaine (1 mM). 5. This study suggests that Ca2+ ions released through the InsP3 receptor-channel upon NA application do not activate CICR and the InsP3- and Ca(2+)-sensitive Ca2+ store appears to represent, at least functionally, a single releasable Ca2+ pool.
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