ArticleThe Journal of cell biology1995
A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 101 citations in OpenAlex.
- Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.BMC biology · 2024Article
- Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules.Biomolecules · 2020Review
- Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons.Frontiers in cellular neuroscience · 2019Review
- Casein kinase 1α: biological mechanisms and theranostic potential.Cell communication and signaling : CCS · 2018Review
- CASEIN KINASE1-LIKE PROTEIN2 Regulates Actin Filament Stability and Stomatal Closure via Phosphorylation of Actin Depolymerizing Factor.The Plant cell · 2016Article
- Phosphorylation regulates the Star-PAP-PIPKIα interaction and directs specificity toward mRNA targets.Nucleic acids research · 2015Article
- The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.Frontiers in oncology · 2014Review
- Modulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays.British journal of pharmacology · 2013Article
- Article
- Casein kinase iγ2 impairs fibroblasts actin stress fibers formation and delays cell cycle progression in g1.International journal of cell biology · 2012Article
- Casein kinase I delta controls centrosome positioning during T cell activation.The Journal of cell biology · 2011Article
- CKI isoforms α and ε regulate Star-PAP target messages by controlling Star-PAP poly(A) polymerase activity and phosphoinositide stimulation.Nucleic acids research · 2011Article
- Partitioning of casein kinase 1-like 6 to late endosome-like vesicles.Protoplasma · 2010Article
- Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Versatile casein kinase 1: multiple locations and functions.Plant signaling & behavior · 2009Article
- A novel gene expression pathway regulated by nuclear phosphoinositides.Advances in enzyme regulation · 2009Review
- Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.PloS one · 2009Article
- Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts.Molecular and cellular biology · 2007Article
- Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation.Journal of virology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In interphase cells, alpha-casein kinase I (alpha-CKI) is found associated with cytosolic vesicular structures, the centrosome, and within the nucleus. To identify the specific vesicular structures with which alpha-CKI is associated, established cell lines and primary rat neurons were immunofluorescently labeled with an antibody raised to alpha-CKI. In nonneuronal cells, alpha-CKI colocalizes with vesicular structures which align with microtubules and are partially coincident with both Golgi and endoplasmic reticulum markers. In neurons, alpha-CKI colocalizes with synaptic vesicle markers. When synaptic vesicles were purified from rat brain, they were highly enriched in a CKI, based on activity and immunoreactivity. The synaptic vesicle-associated CKI is an extrinsic kinase and was eluted from synaptic vesicles and purified. This purified CKI has properties most similar to alpha-CKI. When the activities of casein kinase I or II were specifically inhibited on isolated synaptic vesicles, CKI was shown to phosphorylate a specific subset of vesicle proteins, one of which was identified as the synaptic vesicle-specific protein SV2. As with alpha-CKI, the synaptic vesicle CKI is inhibited by phosphatidylinositol 4,5-bisphosphate (PIP2). However, synthesis of PIP2 was detected only in plasma membrane-containing fractions. Therefore, PIP2 may spatially regulate CKI. Since PIP2 synthesis is required for secretion, this inhibition of CKI may be important for the regulation of secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.