ArticleThe Journal of cell biology1995
F actin bundles in Drosophila bristles. I. Two filament cross-links are involved in bundling.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.The Journal of cell biology · 2026Article
- Distinct disassembly modes shape cytoskeletal assembly and fluctuations.Biophysical reports · 2026Article
- Endoplasmic reticulum patterns insect cuticle nanostructure.The Journal of cell biology · 2026Article
- Specialized structure and function of the apical extracellular matrix at sense organs.Cells & development · 2024Review
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- Silactins and Structural Diversity of Biosilica in Sponges.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- The actin cytoskeleton plays multiple roles in structural colour formation in butterfly wing scales.Nature communications · 2024Article
- Dusky-like Is Critical for Morphogenesis of the Cellular Protuberances and Formation of the Cuticle inBiology · 2023Article
- Actin Bundles Dynamics and Architecture.Biomolecules · 2023Review
- Scale-type-specific requirement for the mosquito Aedes aegypti Spindle-F homologue by regulating microtubule organization.Insect molecular biology · 2022Article
- TheFrontiers in cellular and infection microbiology · 2022Article
- Recapitulating Actin Module Organization in theInternational journal of molecular sciences · 2021Article
- Axon formation, extension, and navigation: only a neuroscience phenomenon?Current opinion in neurobiology · 2018Review
- Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP.G3 (Bethesda, Md.) · 2017Article
- Nano-scale actin-network characterization of fibroblast cells lacking functional Arp2/3 complex.Journal of structural biology · 2017Article
- IKKε inhibits PKC to promote Fascin-dependent actin bundling.Development (Cambridge, England) · 2016Article
- Cofilin-mediated actin dynamics promotes actin bundle formation during Drosophila bristle development.Molecular biology of the cell · 2016Article
- Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways.Biology open · 2015Article
- Dendritic spine geometry can localize GTPase signaling in neurons.Molecular biology of the cell · 2015Article
5 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Transverse sections though Drosophila bristles reveal 7-11 nearly round, plasma membrane-associated bundles of actin filaments. These filaments are hexagonally packed and in a longitudinal section they show a 12-nm periodicity in both the 1.1 and 1.0 views. From earlier studies this periodicity is attributable to cross-links and indicates that the filaments are maximally cross-linked, singed mutants also have 7-11 bundles, but the bundles are smaller, flattened, and the filaments within the bundles are randomly packed (not hexagonal); no periodicity can be detected in longitudinal sections. Another mutant, forked (f36a), also has 7-11 bundles but even though the bundles are very small, the filaments within them are hexagonally packed and display a 12-nm periodicity in longitudinal section. The singed-forked double mutant lacks filament bundles. Thus there are at least two species of cross-links between adjacent actin filaments. Hints of why two species of cross-links are necessary can be gleaned by studying bristle formation. Bristles sprout with only microtubules within them. A little later in development actin filaments appear. At early stages the filaments in the bundles are randomly packed. Later the filaments in the bundles become hexagonally packed and maximally cross-linked. We consider that the forked proteins may be necessary early in development to tie the filaments together in a bundle so that they can be subsequently zippered together by fascin (the singed gene product).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.