ArticleInternational archives of occupational and environmental health1995
Carbon disulphide. II. Investigations on the uptake of CS2 and the excretion of its metabolite 2-thiothiazolidine-4-carboxylic acid after occupational exposure.
Article in International archives of occupational and environmental health, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Evaluation of urinary selenium as a biomarker of human occupational exposure to elemental and inorganic selenium.International archives of occupational and environmental health · 2020Article
- Current and historical individual data about exposure of workers in the rayon industry to carbon disulfide and their validity in calculating the cumulative dose.International archives of occupational and environmental health · 2014Article
- Occupational exposure to N,N-dimethylformamide in the summer and winter.Industrial health · 2014Article
- Absorption of chemicals through compromised skin.International archives of occupational and environmental health · 2009Review
- Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams.Occupational and environmental medicine · 2007Article
- Dermal absorption of aromatic amines in workers with different skin lesions: a report on 4 cases.Journal of occupational medicine and toxicology (London, England) · 2006Article
- Combined exposure to carbon disulfide and sulfuric acid simultaneously increases the risk of hand dermatitis in rayon industry.Journal of exposure analysis and environmental epidemiology · 2004Article
- Skin protection and percutaneous absorption of chemical hazards.International archives of occupational and environmental health · 2003Review
- Carbon disulphide. IV. Cardiovascular function in workers in the viscose industry.International archives of occupational and environmental health · 1996Article
- Carbon disulphide. III. Risk factors for coronary heart diseases in workers in the viscose industry.International archives of occupational and environmental health · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reported investigations on the uptake of carbon disulphide (CS2) and the excretion of its metabolite 2-thiothiazolidine-4-carboxylic acid (TTCA) were based on results from 403 personal air samples (352 passive and 51 active samples) and 362 TTCA determinations in biological material measured during a field study on the adverse effects due to CS2 exposure. The external exposure ranged from below the detection limit (0.2 ppm) to 66 ppm and the urinary TTCA excretion from below the detection limit (0.16 mg./l) to 33.4 mg/l. The excretion of TTCA in postshift urine related to creatinine and volume showed a linear correlation to the CS2 air concentration. On the basis of these results the influence on the internal exposure of physical work load, dermal exposure and individual parameters (age, Brocaindex, disturbed skin barrier) was evaluated. Correlations between the TTCA values in the postshift urine and the individually measured CS2 concentrations were carried out separately for individual departments and persons with and without indications of a disturbed skin barrier. In order to be able to judge the individual internal exposure related to external exposure, a personal quotient was formed from the TTCA level in the urine and the CS2 air concentration measured on the same day (relative internal exposure RIE index = TTCA mg/g creatinine/CS2 in ppm). On investigating interindividual differences, higher relative internal exposures were found in persons with a heavy physical work load and more intensive skin contact. It could be shown for a large group of persons exposed to CS2 that a pathological skin condition leads to an increase in the dermal penetration rate of hazardous substances.(ABSTRACT TRUNCATED AT 250 WORDS)
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