ArticleInfection and immunity1995
Immunization of rats with synthetic peptide constructs from the glucan-binding or catalytic region of mutans streptococcal glucosyltransferase protects against dental caries.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Novel technologies for the prevention and treatment of dental caries: a patent survey.Expert opinion on therapeutic patents · 2010Review
- Mutans streptococcal infection induces salivary antibody to virulence proteins and associated functional domains.Infection and immunity · 2008Article
- Immunogenic and protective potential of mutans streptococcal glucosyltransferase peptide constructs selected by major histocompatibility complex class II allele binding.Infection and immunity · 2007Article
- The scientific and public-health imperative for a vaccine against dental caries.Nature reviews. Immunology · 2006Review
- Immunological and protective effects of diepitopic subunit dental caries vaccines.Infection and immunity · 2005Article
- Role of peptide antigen for induction of inhibitory antibodies to Streptococcus mutans in human oral cavity.Clinical and experimental immunology · 2004Article
- Immunogenicity and protective immunity induced by synthetic peptides associated with putative immunodominant regions of Streptococcus mutans glucan-binding protein B.Infection and immunity · 2003Article
- Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection.Infection and immunity · 2002Article
- Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries.Infection and immunity · 2002Article
- Effect of attenuated Salmonella enterica serovar Typhimurium expressing a Streptococcus mutans antigen on secondary responses to the cloned protein.Infection and immunity · 2001Article
- Facilitated intranasal induction of mucosal and systemic immunity to mutans streptococcal glucosyltransferase peptide vaccines.Infection and immunity · 2001Article
- Diepitopic construct of functionally and epitopically complementary peptides enhances immunogenicity, reactivity with glucosyltransferase, and protection from dental caries.Infection and immunity · 2001Article
- Modified immunogenicity of a mucosally administered antigen.Clinical and diagnostic laboratory immunology · 2001Article
- Coimmunization with complementary glucosyltransferase peptides results in enhanced immunogenicity and protection against dental caries.Infection and immunity · 2000Article
- Protective immunity against Streptococcus mutans infection in mice after intranasal immunization with the glucan-binding region of S. mutans glucosyltransferase.Infection and immunity · 1999Article
- Antibody to glucosyltransferase induced by synthetic peptides associated with catalytic regions of alpha-amylases.Infection and immunity · 1999Article
- Functional and immunogenic characterization of two cloned regions of Streptococcus mutans glucosyltransferase I.Infection and immunity · 1999Article
- Analysis of the Yersinia pestis V protein for the presence of linear antibody epitopes.Infection and immunity · 1998Article
- Immunogenicity and protective immunity induced by synthetic peptides associated with a catalytic subdomain of mutans group streptococcal glucosyltransferase.Infection and immunity · 1997Article
- Effects of antibodies against cell surface protein antigen PAc-glucosyltransferase fusion proteins on glucan synthesis and cell adhesion of Streptococcus mutans.Infection and immunity · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previously, we have described peptide constructs from two regions of glucosyltransferase (GTF) of mutans streptococci. A putative catalytic site in the amino-terminal half of the molecule and a repeated glucan-binding site in the carboxyl-terminal half of GTF were the regions upon which sequences were based. The present study explored the effects of immunization with these peptide constructs (called CAT or GLU) and with streptococcal GTFs from Streptococcus sobrinus and S. mutans on immunological, microbiological, and disease parameters. Groups of immunized Sprague-Dawley rats were infected with either 10(8) S. sobrinus 6715 or 10(8) S. mutans SJ32 organisms. Serum immunoglobulin G antibody levels, determined by enzyme-linked immunosorbent assay, to the respective peptide constructs and to the appropriate streptococcal GTF were significantly increased (after immunization) prior to infection and at the end of the experiment. Also, serum antibody from CAT-, GLU-, and S. sobrinus GTF-immunized rats inhibited S. sobrinus GTF-mediated insoluble glucan synthesis (all) and S. mutans GTF-mediated soluble glucan synthesis (all except anti-GLU) from sucrose. Immunization with the CAT or GLU peptide construct resulted in significantly reduced smooth surface and sulcal caries after infection with S. sobrinus. Sulcal dental caries after infection with S. mutans SJ32 were also significantly reduced in CAT- and GLU-immunized rats. Thus, immunization with peptides whose sequences are based on putative functional domains of mutans streptococcal GTF are protective toward a cariogenic S. sobrinus or S. mutans infection.
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