Evidence map›Paper›PMID 7621403›Full record

ReviewClinical microbiology reviews1995

Virus receptors: implications for pathogenesis and the design of antiviral agents.

L C Norkin

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 68 citations in OpenAlex.

  1. Using exosomes for universal vaccines.Infection and immunity · 2025
    Article
  2. Article
  3. Seven classes of antiviral agents.Cellular and molecular life sciences : CMLS · 2022
    Review
  4. Article
  5. Review
  6. Coronavirus Disease 2019-COVID-19.Clinical microbiology reviews · 2020
    Review
  7. Article
  8. Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  9. Identification of the linear ligand epitope on classical swine fever virus that interacts with porcine kidney 15 cells.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2017
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Animal virus receptors.Folia microbiologica · 1999
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

L C NorkinDepartment of Microbiology, University of Massachusetts, Amherst 01003, USA.
University of Massachusetts Amherst · US

Funding

INTERACTION OF SV40 WITH MHC CLASS 1 PROTEINSR01CA050532 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI NORKIN, LEONARD C. · 1989 to 1991
–
NCI NIH HHS CA50532
6 · The paper itself

Abstract

A virus initiates infection by attaching to its specific receptor on the surface of a susceptible host cell. This prepares the way for the virus to enter the cell. Consequently, the expression of the receptor on specific cells and tissues of the host is a major determinant of the route of entry of the virus into the host and of the patterns of virus spread and pathogenesis in the host. This review emphasizes the virus-receptor interactions of human immunodeficiency virus, the rhinoviruses, the herpesviruses, and the coronaviruses. These interactions are often found to be complex and dynamic, involving multiple sites or factors on both the virus and the host cell. Also, the receptor may play an important role in virus entry per se in addition to its role in virus binding. In the cases of human immunodeficiency virus and the rhinoviruses, ingenious approaches to therapeutic strategies based on inhibiting virus attachment and entry are under development and in clinical trials.

Indexed as

Antiviral AgentsCD4 AntigensCoronavirusDrug DesignHerpesviridaeHIVHumansIntercellular Adhesion Molecule-1Models, MolecularPicornaviridaeReceptors, VirusRetroviridaeAntiviral AgentsCD4 AntigensIntercellular Adhesion Molecule-1Receptors, Virus

Identifiers

PMID7621403
PMCPMC172860
OpenAlexW2102320035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.