ArticleBritish journal of clinical pharmacology1995
Serum drug concentrations after oral administration of paracetamol to patients with surgical resection of the gastrointestinal tract.
Article in British journal of clinical pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05302531 (Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Changes of Drug Pharmacokinetics in Patients with Short Bowel Syndrome: A Systematic Review.European journal of drug metabolism and pharmacokinetics · 2021Pooled it
- Systematic review of drug bioavailability following gastrointestinal surgery.European journal of clinical pharmacology · 2018Pooled it
- Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP).International journal of clinical pharmacology and therapeutics · 2024Article
- Titanate nanotubes as an efficient oral detoxifying agent against drug overdose: application in rat acetaminophen poisoning.Nanoscale advances · 2023Article
- Paracetamol modulates biofilm formation in Staphylococcus aureus clonal complex 8 strains.Scientific reports · 2021Article
- Managing intestinal failure in inflammatory bowel disease - 'when the drugs don't work'.Frontline gastroenterology · 2021Article
- The impact of intestinal failure on oral drug absorption: a review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Review
- Enteral drug absorption in patients with short small bowel : a review.Clinical pharmacokinetics · 2004Review
- Effects of surgery on the pharmacokinetic parameters of drugs.Clinical pharmacokinetics · 1998Review
- Pharmacologic challenges in pediatric intestinal failure: A review.Intestinal Failure (New York, N.Y.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum concentrations of paracetamol were measured at 30, 60, 120 and 180 min after oral administration of a solution of 1500 mg paracetamol in normal subjects (n = 32) (Group A) and in patients with total gastrectomy (Roux-en-Y reconstruction) (n = 5) (Group B), distal partial gastrectomy (Billroth I reconstruction) (n = 7) (Group C), pylorus preserving pancreatoduodenectomy (Billroth I type reconstruction) (n = 12) (Group D), and short bowel syndrome (n = 5) (Group E). In Group B, the dose was delivery directly into the jejunum 20 cm distal to the duodenojejunal flexure. The highest serum drug concentrations were observed in the 30 min sample in Groups B and C and in the 120 min sample in Groups A, D, and E. Mean (+/- s.d.) concentrations at these times were 18.90 +/- 1.55 micrograms ml-1 (Group B), 12.89 +/- 2.12 micrograms ml-1 (Group C), 11.12 +/- 3.16 micrograms ml-1 (Group A), 9.78 +/- 2.85 micrograms ml-1 (Group D), and 4.89 +/- 1.96 micrograms ml-1 (Group E), respectively. We conclude that in patients with normal intact gastrointestinal tract, most of a dose of oral paracetamol is absorbed from the jejunum distal to the duodenojejunal flexure.
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