ArticleThe Biochemical journal1995
Regulation of GLUT5 gene expression in rat intestinal mucosa: regional distribution, circadian rhythm, perinatal development and effect of diabetes.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Effects of Maternal Nutrition and One-Carbon Metabolite Supplementation on Fetal Jejunal Morphology and Hexose Transporter Expression in Beef Cattle.Veterinary sciences · 2025Article
- Circadian Rhythms in Cardiovascular Metabolism.Circulation research · 2024Review
- GLUT5: structure, functions, diseases and potential applications.Acta biochimica et biophysica Sinica · 2023Review
- Article
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Daily expression of sodium-dependent glucose cotransporter-1 protein in jejunum during rat ontogeny.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Article
- Recent insights into the role of ChREBP in intestinal fructose absorption and metabolism.BMB reports · 2018Review
- ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome.Metabolism: clinical and experimental · 2018Article
- Potential Crosstalk between Fructose and Melatonin: A New Role of Melatonin-Inhibiting the Metabolic Effects of Fructose.International journal of endocrinology · 2018Review
- Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms.Frontiers in medicine · 2017Article
- Crosstalk between circadian rhythmicity, mitochondrial dynamics and macrophage bactericidal activity.Immunology · 2014Article
- Fructose-induced symptoms beyond malabsorption in FGID.United European gastroenterology journal · 2014Article
- Fructose modulates cardiomyocyte excitation-contraction coupling and Ca²⁺ handling in vitro.PloS one · 2011Article
- Ontogeny, growth and development of the small intestine: Understanding pediatric gastroenterology.World journal of gastroenterology · 2010Review
- Radiation-induced reductions in transporter mRNA levels parallel reductions in intestinal sugar transport.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Clock is important for food and circadian regulation of macronutrient absorption in mice.Journal of lipid research · 2009Article
- Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Regulation of the fructose transporter GLUT5 in health and disease.American journal of physiology. Endocrinology and metabolism · 2008Review
- Coordinated, diurnal hexose transporter expression in rat small bowel: implications for small bowel resection.Surgery · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. GLUT5 gene expression was studied in small intestine under a variety of conditions characterized by altered intestinal absorption of monosaccharides. 2. RNA-blotting studies showed that GLUT5 mRNA was abundantly expressed in rat and rabbit intestine and kidney, but it was not detected in heart or brown adipose tissue. GLUT5 mRNA levels were higher in the upper segments of the small intestine (duodenum and proximal jejunum) than in the lower segments (distal jejunum and ileum). 3. The intestinal expression of GLUT5 mRNA in rat proximal jejunum showed circadian rhythm. A 12-fold increase in GLUT5 mRNA levels was detected at the end of the light cycle and at the beginning of the dark cycle when compared with the early light period. In keeping with this, GLUT5 protein content in brush-border membranes was also increased at the beginning of the dark cycle compared with that in the light period. 4. In streptozotocin-induced diabetes an 80% increase in GLUT5 mRNA levels in mucosa from the proximal jejunum was detected under conditions in which enhanced intestinal absorption of monosaccharides has been reported. 5. The intestinal expression of GLUT5 mRNA showed regulation during perinatal development. Levels of GLUT5 mRNA were low during fetal life, increased progressively during the postnatal period and reached levels comparable with the adult state after weaning. Weaning on to a high-fat diet partially prevented the induction of GLUT5 gene expression. 6. Our results indicate that GLUT5 gene expression is tightly regulated in small intestine. Regulation involves maximal expression in the upper part of the small intestine, circadian rhythm, developmental regulation dependent on the fat and carbohydrate content in the diet at weaning and enhanced expression in streptozotocin-induced diabetes. Furthermore, changes observed in intestinal GLUT5 expression correlate with reported alterations in intestinal absorption of fructose. This suggests a regulatory role for GLUT5 in fructose uptake by absorptive enterocytes.
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