ArticleThe Biochemical journal1995
Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 130 citations in OpenAlex.
- Article
- Article
- A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy.Sports medicine (Auckland, N.Z.) · 2015Review
- Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training.Sports medicine (Auckland, N.Z.) · 2013Review
- New concepts in the mechanism of ammonia-induced astrocyte swelling.Metabolic brain disease · 2007Review
- Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells.Experimental eye research · 2007Article
- Differential dependence of regulatory volume decrease behavior in rabbit corneal epithelial cells on MAPK superfamily activation.Experimental eye research · 2007Article
- Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Ca2+ signaling, intracellular pH and cell volume in cell proliferation.The Journal of membrane biology · 2005Review
- Ca2+-mediated potentiation of the swelling-induced taurine efflux from HeLa cells: on the role of calmodulin and novel protein kinase C isoforms.The Journal of membrane biology · 2004Article
- Calcium modulates osmosensitive taurine efflux in HeLa cells.Neurochemical research · 2004Review
- Human cervical cancer cells use Ca2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease.The Journal of physiology · 2001Article
- Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver.The Biochemical journal · 2000Article
- Osmotic cell swelling-induced ATP release mediates the activation of extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels.The Biochemical journal · 1999Article
- Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes.The Biochemical journal · 1999Article
- Involvement of PKC-alpha in regulatory volume decrease responses and activation of volume-sensitive chloride channels in human cervical cancer HT-3 cells.The Journal of physiology · 1998Article
- K+ channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation.The Journal of physiology · 1998Article
- Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.The Biochemical journal · 1998Article
- Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- A developmentally regulated MAP kinase activated by hydration in tobacco pollen.The Plant cell · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic metabolism and gene expression are among the factors controlled by the cellular hydration state, which changes within minutes in response to aniso-osmotic environments, cumulative substrate uptake, oxidative stress and under the influence of hormones such as insulin. The signalling events coupling cell-volume changes to altered cell function were studied in H4IIE rat hepatoma cells. Hypo-osmotic cell swelling resulted within 1 min in a tyrosine kinase-mediated activation of the extracellular signal-regulated protein kinases Erk-1 and Erk-2, which was independent of protein kinase C and cytosolic calcium. Activation of mitogen-activated protein kinases was followed by an increased phosphorylation of c-Jun, which may explain our recently reported finding of an about 5-fold increase in c-jun mRNA level in response to cell swelling. Pretreatment of cells with pertussis or cholera toxin abolished the swelling-induced activation of Erk-1 and Erk-2, suggesting the involvement of G-proteins. Thus, a signal-transduction pathway resembling growth factor signalling is activated already by osmotic water shifts across the plasma membrane, thereby providing a new perspective for adaption of cell function to alterations of the environment.
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