ArticleAnnals of surgery1995
Role of bombesin on gut mucosal growth.
Article in Annals of surgery, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Colonic enteric nervous system analysis during parenteral nutrition.The Journal of surgical research · 2013Article
- Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: not just trefoil peptides.World journal of gastroenterology · 2008Article
- International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.Pharmacological reviews · 2008Review
- Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats.World journal of gastroenterology · 2008Article
- Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat.Pediatric surgery international · 2007Article
- Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: effect of bombesin and neurotensin.World journal of gastroenterology · 2006Article
- Effects of melatonin administration on intestinal adaptive response after massive bowel resection in rats.Digestive diseases and sciences · 2006Article
- Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats.World journal of gastroenterology · 2005Article
- Epidermal growth factor and bombesin act synergistically to support intestinal adaptation in rats with massive small bowel resection.Pediatric surgery international · 2005Article
- Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas.Annals of surgery · 2005Article
- Bombesin and neurotensin reduce endotoxemia, intestinal oxidative stress, and apoptosis in experimental obstructive jaundice.Annals of surgery · 2005Article
- Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours.Journal of clinical pathology · 2004Article
- Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells.Gut · 2003Article
- Gastrin-releasing peptide is a growth factor for human neuroblastomas.Annals of surgery · 2002Article
- Bombesin ameliorates colonic damage in experimental colitis.Digestive diseases and sciences · 1999Article
- Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C.Digestive diseases and sciences · 1999Article
- Glucagon-like peptide 2 is a potent growth factor for small intestine and colon.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Peptide YY selectively stimulates expression of the colonocytic phenotype.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe authors examined the effects of exogenous bombesin (BBS) on gut mucosal growth in chow-fed rats and the mucosal regeneration after gut atrophy brought about by feeding an elemental diet and after intestinal injury produced by methotrexate (MTX). SUMMARY BACKGROUND DATA: Bombesin is one of many gastrointestinal peptides implicated in the regulation of gut mucosal growth. Although BBS is known to stimulate growth of normal pancreatic tissue, the trophic effect of BBS on gut mucosa is less clear and its exact role in gut mucosal regeneration and repair is not known.
methodsRats were fed a regular chow diet (control) or an elemental diet plus either saline or BBS (10 micrograms/kg). In another experiment, rats fed a chow diet and treated with saline or BBS were given MTX (20 micrograms/kg) or a single intraperitoneal injection. In all experiments, small and large bowel mucosa and pancreas were removed and analyzed for BBS-mediated proliferation.
resultsBombesin produced significant mucosal proliferation of the small bowel at day 14, but not at day 7, in rats fed regular chow. In contrast, BBS treatment for 7 days produced significant proliferation in both the atrophic and injured gut mucosa of rats given elemental diet or MTX.
conclusionsBombesin may be an important enterotrophic factor for normal mucosal proliferation and may be clinically beneficial as an agent to restore or maintain gut mucosa during periods of atrophy or injury.
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