ArticleThe Journal of clinical investigation1995
Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Preclinical Evaluation of aACS pharmacology & translational science · 2026Article
- uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma.PloS one · 2011Article
- Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block.Circulation research · 2010Article
- MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.PloS one · 2010Article
- Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction.Experimental cell research · 2010Article
- RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth.International journal of cancer · 2007Article
- Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.Experimental cell research · 2007Article
- Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones.Journal of neuro-oncology · 2006Article
- Proteases and glioma angiogenesis.Brain pathology (Zurich, Switzerland) · 2005Review
- Urokinase upregulates matrix metalloproteinase-9 expression in THP-1 monocytes via gene transcription and protein synthesis.The Biochemical journal · 2002Article
- Induction of the plasminogen activator system accompanies peripheral nerve regeneration after sciatic nerve crush.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices.The American journal of pathology · 1999Article
- Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.The Journal of experimental medicine · 1998Article
- Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice.The Journal of cell biology · 1998Article
- Increased focal adhesion kinase- and urokinase-type plasminogen activator receptor-associated cell signaling in endothelial cells exposed to asbestos.Environmental health perspectives · 1997Article
- Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.The Journal of clinical investigation · 1997Article
- Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy.The Journal of cell biology · 1997Article
- Differential expression of the urokinase receptor (CD87) in arthritic and normal synovial tissues.Journal of clinical pathology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Binding of urokinase to the glycolipid-anchored urokinase receptor (uPAR) has been implicated in macrophage differentiation. However, no biochemical markers of differentiation have yet been directly linked to uPAR occupancy. As extensive changes in proteolytic profile characterize monocytic differentiation, we have examined the role of uPAR occupancy on protease expression by differentiating phagocytes. Antibodies to either urokinase or to uPAR that prevent receptor binding inhibited induction of cathepsin B in cultured monocytes and both cathepsin B and 92-kD gelatinase mRNA and protein in phorbol diester-stimulated myeloid cells. Mannosamine, an inhibitor of glycolipid anchor assembly, also blocked protease expression. Anti-catalytic urokinase antibodies, excess inactive urokinase, or aprotinin had no effect, indicating that receptor occupancy per se regulated protease expression. Antibodies to the integrins CD11a and CD29 or to the glycolipid-anchored proteins CD14 and CD55 also had no effect. Protease induction was independent of matrix attachment. Antibodies to urokinase or uPAR affected neither the decrease in cathepsin G nor the increase in tumor necrosis factor-alpha in phorbol ester-stimulated cells. These data establish that uPAR is a multifunctional receptor, not only promoting pericellular proteolysis and matrix attachment, but also effecting cysteine- and metallo-protease expression during macrophage differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.