ArticleGut1995
High Helicobacter pylori numbers are associated with low eradication rate after triple therapy.
Article in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Sequential versus standard triple first-line therapy for Helicobacter pylori eradication.The Cochrane database of systematic reviews · 2016Pooled it
- Effect of treatment failure on the CagA EPIYA motif inWorld journal of gastroenterology · 2017Trial
- Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection.World journal of gastroenterology · 2012Trial
- 13C-urea breath test values and Helicobacter pylori eradication.Digestive diseases and sciences · 2008Trial
- Helicobacter pylori eradication with either 7-day or 10-day triple therapies, and with a 10-day sequential regimen.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Trial
- Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers.World journal of gastroenterology · 2004Trial
- Density of Helicobacter pylori may affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers.World journal of gastroenterology · 2003Trial
- Review
- Best Treatment Options for Severe Helicobacter pylori Infections.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- A 'rich-get-richer' mechanism drives patchy dynamics and resistance evolution in antibiotic-treated bacteria.Molecular systems biology · 2024Article
- Sequential versus Standard Triple Therapy for First-LineAntibiotics (Basel, Switzerland) · 2024Review
- Relationship of the Difficulty ofMicroorganisms · 2022Article
- Association Between Patients' Immunoglobulin E Levels and Difficulty EradicatingClinical and experimental gastroenterology · 2021Article
- Colonization ofJGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Diagnosis ofJournal of pathogens · 2018Review
- Severe gastritis decreases success rate of Helicobacter pylori eradication.Wiener klinische Wochenschrift · 2016Article
- Adding diclofenac to Helicobacter pylori eradication regimen.Advanced biomedical research · 2015Article
- Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients.World journal of gastrointestinal pathophysiology · 2012Article
- The inoculum effect and band-pass bacterial response to periodic antibiotic treatment.Molecular systems biology · 2012Article
- Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori.Clinical and experimental gastroenterology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study tested the influence of pretreatment bacterial density on the eradication rate of Helicobacter pylori with triple therapy. One hundred and thirty two patients with endoscopically confirmed H pylori positive, duodenal ulcer or antral gastritis were treated with triple therapy (colloidal bismuth/metronidazole/amoxicillin) for two weeks. Pretreatment urease activity was assessed by the 14C-urea breath test (UBT) in all patients. The mean (SD) pretreatment UBT concentration was similar in patients with duodenal ulcers (318.4 (175.0)) and patients with antral gastritis (288.9 (165.5)). Overall eradication of H pylori was achieved in 85 of 132 patients (64.4%), but was significantly different between patients with high, intermediate, or low pretreatment urease activity (37.5%, 69.5%, and 87.8% respectively). The mean post-treatment UBT value of patients in whom eradication failed was in direct correlation with the pretreatment UBT values. In conclusion, bacterial density, as assessed by urease activity, is an important factor in predicting H pylori eradication. It is suggested that the pretreatment UBT has the potential to identify patients who require modification of the standard therapeutic regimen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.