ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
Cloning and characterization of a second human NRAMP gene on chromosome 12q13.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 116 citations in OpenAlex.
- The solute carrier family 11 transporters: a bridge between iron homeostasis and tumor biology.Cell communication and signaling : CCS · 2025Review
- Manganese Neurotoxicity: A Comprehensive Review of Pathophysiology and Inherited and Acquired Disorders.Journal of xenobiotics · 2025Review
- Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium.Journal of microbiology (Seoul, Korea) · 2023Review
- Manganese Utilization inFrontiers in cell and developmental biology · 2022Review
- Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.Molecules (Basel, Switzerland) · 2020Review
- Article
- Iron transport proteins: Gateways of cellular and systemic iron homeostasis.The Journal of biological chemistry · 2017Review
- Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Manganese homeostasis in the nervous system.Journal of neurochemistry · 2015Review
- Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats.International journal of clinical and experimental pathology · 2015Article
- Iron and reactive oxygen species: friends or foes of cancer cells?Antioxidants & redox signaling · 2014Review
- Transendothelial Transport and Its Role in Therapeutics.International scholarly research notices · 2014Review
- 1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310.PloS one · 2012Article
- Natural history of SLC11 genes in vertebrates: tales from the fish world.BMC evolutionary biology · 2011Article
- SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans.PloS one · 2009Article
- A general map of iron metabolism and tissue-specific subnetworks.Molecular bioSystems · 2009Review
- Manganese transport in eukaryotes: the role of DMT1.Neurotoxicology · 2008Review
- Altered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitf(mi) and Mitf(vitiligo) mouse mutants.Experimental eye research · 2008Article
- H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine.Experimental physiology · 2007Review
- Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro.Brain research · 2006Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The mouse Nramp1 gene was initially identified by positional cloning as a candidate for the host resistance locus Bcg on mouse Chromosome (Chr) 1. Subsequent studies have shown that Nramp is a small gene family of at least three members in the mouse genome. We report the isolation and characterization of a cDNA clone corresponding to the second member of the human NRAMP family, NRAMP2. Predicted amino acid sequence analysis of the NRAMP2 polypeptide identifies a polytopic membrane protein highly homologous to NRAMP1, with 66% identical residues (80% overall homology), resulting in identical predicted secondary structures for the two proteins. Sequence conservation is particularly high in the predicted transmembrane domains (90%), suggesting that these regions play a key role in the structural and functional aspects common to both proteins. As opposed to its NRAMP1 counterpart, whose expression is restricted to phagocytic cells, Northern blotting analyses indicate that NRAMP2 mRNA transcripts are expressed at low levels in all tissues analyzed. Fluorescence in situ hybridization has identified 12q13 as the chromosomal location for human NRAMP2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.