ArticleBiophysical journal1995
Cryoelectron microscopy of low density lipoprotein in vitreous ice.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Century of Progress on the Structure of APOB-100 in Atherogenic Lipoproteins.Circulation research · 2026Review
- Elucidating the structural organization of a novel low-density lipoprotein nanoparticle reconstituted with docosahexaenoic acid.Chemistry and physics of lipids · 2017Article
- Human LDL structural diversity studied by IR spectroscopy.PloS one · 2014Article
- Human low density lipoprotein: the mystery of core lipid packing.Journal of lipid research · 2011Article
- Enhancing the contrast of ApoB to locate the surface components in the 3D density map of human LDL.Journal of molecular biology · 2011Article
- Interfacial properties of apolipoprotein B292-593 (B6.4-13) and B611-782 (B13-17). Insights into the structure of the lipovitellin homology region in apolipoprotein B.Biochemistry · 2010Article
- Model of human low-density lipoprotein and bound receptor based on cryoEM.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Molecular structure of low density lipoprotein: current status and future challenges.European biophysics journal : EBJ · 2009Article
- Reconstituting initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system.Journal of molecular biology · 2008Article
- Charged amino acid residues 997-1000 of human apolipoprotein B100 are critical for the initiation of lipoprotein assembly and the formation of a stable lipidated primordial particle in McA-RH7777 cells.The Journal of biological chemistry · 2008Article
- Structural analysis of reconstituted lipoproteins containing the N-terminal domain of apolipoprotein B.Biophysical journal · 2007Article
- Article
- Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle.Biophysical journal · 2005Article
- Three-dimensional structure of low density lipoproteins by electron cryomicroscopy.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Single-particle selection and alignment with heavy atom cluster-antibody conjugates.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this report, images of low density lipoprotein (LDL) in vitreous ice at approximately 30 A resolution are presented. These images show that LDL is a quasi-spherical particle, approximately 220-240 A in diameter, with a region of low density (lipid) surrounded by a ring (in projection) of high density believed to represent apolipoprotein B-100. This ring is seen to be composed of four or five (depending on view) large regions of high density material that may represent protein superdomains. Analysis of LDL images obtained at slightly higher magnification reveals that areas of somewhat lower density connect these regions, in some cases crossing the projectional interiors of the LDL particles. Preliminary image analysis of LDL covalently labeled at Cys3734 and Cys4190 with 1.4-nm Nanogold clusters demonstrates that this methodology will provide an important site-specific marker in studies designed to map the organization of apoB at the surface of LDL.
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Registered trials
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