ArticleAmerican journal of human genetics1995
Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
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- Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD.Human genetics · 2011Article
- Suggestive linkage of schizophrenia to 5p13 in Costa Rica.Molecular psychiatry · 2005Article
- ATM haplotypes and associated mutations in Iranian patients with ataxia-telangiectasia: recurring homozygosity without a founder haplotype.Human genetics · 2005Article
- Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18.American journal of human genetics · 1999Article
- Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations.American journal of human genetics · 1998Article
- A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening.American journal of human genetics · 1996Article
- Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.American journal of human genetics · 1996Article
- The ataxia-telangiectasia-variant genes 1 and 2 are distinct from the ataxia-telangiectasia gene on chromosome 11q23.1.American journal of human genetics · 1995Article
- Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.American journal of human genetics · 1995Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
In an effort to localize a gene for ataxia-telangiectasia (A-T), we have genotyped 27 affected Costa Rican families, with 13 markers, in the chromosome 11q22-23 region. Significant linkage disequilibrium was detected for 9/13 markers between D11S1816 and D11S1391. Recombination events observed in these pedigrees places A-T between D11S1819 and D11S1960. One ancestral haplotype is common to 24/54 affected chromosomes and roughly two-thirds of the families. Inferred (ancestral) recombination events involving this common haplotype in earlier generations suggest that A-T is distal to D11S384 and proximal to D11S1960. Several other common haplotypes were identified, consistent with multiple mutations in a single gene. When considered together with all other evidence, this study further sublocalizes the major A-T locus to approximately 200 kb, between markers S384 and S535.
Indexed as
Identifiers
7611278PMC1801239W1604747908What OpenQuestion holds
Registered trials
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