ArticleNucleic acids research1995
Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Risk and protection of different rare protein-coding variants of complement component C4A in age-related macular degeneration.Frontiers in genetics · 2023Article
- Case Report: Novel Compound-Heterozygous Variants ofFrontiers in genetics · 2021Article
- Review
- The RNA exosome and RNA exosome-linked disease.RNA (New York, N.Y.) · 2018Review
- RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism.The Journal of biological chemistry · 2016Article
- SKIV2L mutations cause syndromic diarrhea, or trichohepatoenteric syndrome.American journal of human genetics · 2012Article
- DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.Molecular and cellular biology · 2011Article
- INCREASED SIZE EXCLUSION LIMIT 2 encodes a putative DEVH box RNA helicase involved in plasmodesmata function during Arabidopsis embryogenesis.The Plant cell · 2007Article
- Linking the 3' poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p.Molecular and cellular biology · 2001Article
- Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.Genetics · 2001Article
- 3' poly(A) is dispensable for translation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p.Molecular and cellular biology · 2000Article
- The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes.Nucleic acids research · 1998Article
- Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis.Molecular and cellular biology · 1998Article
- The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.The EMBO journal · 1998Article
- Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae.The EMBO journal · 1998Article
- A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA.Molecular and cellular biology · 1996Article
- Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.Genetics · 1996Article
- Double-stranded RNA viruses of Saccharomyces cerevisiae.Microbiological reviews · 1996Review
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5 authors at 1 institution in 1 country.
Funding
Abstract
Helicases are essential enzymes for life because DNA replication, DNA repair, recombination, transcription, RNA splicing and translation all involve more than one helicase to unwind DNA or RNA. We have discovered, cloned and partially characterized a novel human helicase gene, SKI2W. The human SKI2W is located between the RD and RP1 genes in the class III region of the major histocompatibility complex (MHC) on chromosome 6, a genomic region associated with many malignant, genetic and autoimmune diseases. Derived amino acid sequence of human SKI2W showed an open reading frame for 1246 residues. It contains consensus sequences for structural motifs of an RNA helicase with a DEVH box. It has a leucine zipper motif that may be important for protein dimerization, and an RGD motif close to the N-terminus that might serve as a ligand for integrin or cell adhesion molecules. SKI2W shares a striking and extensive similarity to the yeast Ski2p that is involved in the inhibition of translation of poly(A) negative [poly(A)-] RNA, and plays an important role in antiviral activities. Human SKI2W fusion protein expressed in insect cells using a baculovirus vector has ATPase activity. The human SKI2W protein and the yeast Ski2p share extensive sequence similarities to another putative human protein KIAA0052, suggesting the presence of a new gene family that may be involved in translational regulation of cellular and viral RNA.
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