ArticleImmunogenetics1995
Cloning and characterization of class I Mhc genes of the zebrafish, Brachydanio rerio.
Article in Immunogenetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- The zebrafish as a model for gastrointestinal tract-microbe interactions.Cellular microbiology · 2020Review
- Distribution of ancient α1 and α2 domain lineages between two classical MHC class I genes and their alleles in grass carp.Immunogenetics · 2019Article
- Review
- MHC and Evolution in Teleosts.Biology · 2016Review
- The MHC class I genes of zebrafish.Developmental and comparative immunology · 2014Review
- Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish.Immunogenetics · 2014Article
- Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish.Immunogenetics · 2014Article
- Characterization of primary and memory CD8 T-cell responses against ranavirus (FV3) in Xenopus laevis.Journal of virology · 2007Article
- cDNA cloning and genomic structure of the duck (Anas platyrhynchos) MHC class I gene.Immunogenetics · 2004Article
- Article
- Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Unexpected beta2-microglobulin sequence diversity in individual rainbow trout.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Characterization of class II A and B genes in a gynogenetic carp clone.Immunogenetics · 1996Article
- Identification and characterization of a new major histocompatibility complex class I gene in carp (Cyprinus carpio L.).Immunogenetics · 1996Article
- Identification of major histocompatibility complex genes in the guppy, Poecilia reticulata.Immunogenetics · 1996Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The zebrafish (Brachydanio rerio) offers many advantages for immunological and immunogenetic research and has the potential for becoming one of the most important nonmammalian vertebrate research models. With this in mind, we initiated a systematic study of the zebrafish major histocompatibility complex (Mhc) genes. In this report, we describe the cloning and characteristics of the zebrafish class I A genes coding for the alpha chains of the alpha beta heterodimer and thus complete the identification of all four classes and subclasses of the Mhc in this species. We describe the full class I alpha cDNA sequence as well as the exon-intron organization of the class I A genes, including intron sequences. We identify three families of class I A genes which we designate Brre-UAA, -UBA, and -UCA. The three families originated about the time of the divergence of cyprinid and salmonid fishes. All three families are members of an ancient lineage that diverged from another, older lineage also represented in cyprinid fishes before the radiation of teleost orders. The fish class I A genes therefore evolve differently from mammalian class I A genes, in which the establishment of lineages and families mostly postdates the divergence of orders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.