ArticleHuman genetics1995
Allelotyping of follicular thyroid tumors.
Article in Human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 67 citations in OpenAlex.
- The pituitary tumor transforming gene in thyroid cancer.Journal of endocrinological investigation · 2012Review
- Genome haploidisation with chromosome 7 retention in oncocytic follicular thyroid carcinoma.PloS one · 2012Article
- Thyroid cancer: current molecular perspectives.Journal of oncology · 2010Article
- 'Chromosomal Rainbows' Detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors.The open cell signaling journal · 2010Article
- A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients.Human genetics · 2005Article
- A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression.The Journal of clinical investigation · 2004Article
- Genetic and biological subgroups of low-stage follicular thyroid cancer.The American journal of pathology · 2003Article
- Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21.American journal of human genetics · 2001Article
- Genetic background of adrenocortical tumor development.World journal of surgery · 2001Review
- Evaluation of Endocrine Neoplasms Using Fine Needle Aspiration Biopsy.Endocrine pathology · 2000Article
- Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors.Human genetics · 1996Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate further the genetic mechanisms for follicular thyroid tumor development and progression, we allelotyped follicular thyroid tumors and other thyroid lesions from 92 patients. In general, a low frequency of loss of heterozygosity (LOH) was found, the highest being for chromosomes 3q, 10q, 11p, 11q, 13q, and 22q (10%-15%). However, detailed study of LOH of these chromosome arms with regard to the different histopathological diagnoses indicates that a locus on chromosome 10q may be involved in follicular thyroid tumor progression. In addition, the majority of Hürthle cell adenomas showed LOH on either chromosome 3q or 18q, in contrast to the other tumor types. This discrepancy in genetic alterations may contribute to the divergent clinical features occurring in these tumors.
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