ArticleProceedings of the National Academy of Sciences of the United States of America1995
A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- The structure and function of the rous sarcoma virus RNA stability element.Journal of cellular biochemistry · 2011Review
- Translational errors: from yeast to new therapeutic targets.FEMS yeast research · 2010Review
- An atypical RNA pseudoknot stimulator and an upstream attenuation signal for -1 ribosomal frameshifting of SARS coronavirus.Nucleic acids research · 2005Article
- Analysis of natural variants of the human immunodeficiency virus type 1 gag-pol frameshift stem-loop structure.Journal of virology · 2002Article
- Ribosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2001Article
- Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.Molecular and cellular biology · 2001Article
- Internal ribosome entry sites (IRESs): reality and use.Transgenic research · 1999Review
- Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.Molecular and cellular biology · 1999Article
- Article
- Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway.Molecular and cellular biology · 1998Article
- Programmed frameshifting in the synthesis of mammalian antizyme is +1 in mammals, predominantly +1 in fission yeast, but -2 in budding yeast.RNA (New York, N.Y.) · 1998Article
- A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A single amino acid substitution in yeast eIF-5A results in mRNA stabilization.The EMBO journal · 1998Article
- Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents.Trends in biotechnology · 1998Review
- The Mof2/Sui1 protein is a general monitor of translational accuracy.Molecular and cellular biology · 1998Article
- Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.Molecular and cellular biology · 1997Article
- Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency.The EMBO journal · 1996Article
- Reading two bases twice: mammalian antizyme frameshifting in yeast.The EMBO journal · 1996Article
- Double-stranded RNA viruses of Saccharomyces cerevisiae.Microbiological reviews · 1996Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To identify cellular factors that function in -1 ribosomal frameshifting, we have developed assays in the yeast Saccharomyces cerevisiae to screen for host mutants in which frameshifting is specifically affected. Expression vectors have been constructed in which the mouse mammary tumor virus gag-pro frameshift region is placed upstream of the lacZ gene or the CUP1 gene so that the reporters are in the -1 frame relative to the initiation codon. These vectors have been used to demonstrate that -1 frameshifting is recapitulated in yeast in response to retroviral mRNA signals. Using these reporters, we have isolated spontaneous host mutants in two complementation groups, ifs1 and ifs2, in which frameshifting is increased 2-fold. These mutants are also hypersensitive to antibiotics that target the 40S ribosomal subunit. We have cloned the IFS1 gene and shown that it encodes a previously undescribed protein of 1091 aa with clusters of acidic residues in the carboxyl-terminal region. Haploid cells lacking 82% of the IFS1 open reading frame are viable and phenotypically identical to ifs1-1 mutants. This approach could help identify potential targets for antiretroviral agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.