ArticlePflugers Archiv : European journal of physiology1995
Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Triclosan disrupts immune cell function by depressing CaToxicology and applied pharmacology · 2020Article
- Article
- Fluid flow facilitates inward rectifier KScientific reports · 2016Article
- Constitutive expression of a Mg2+-inhibited K+ current and a TRPM7-like current in human erythroleukemia cells.American journal of physiology. Cell physiology · 2012Article
- Differential roles of blocking ions in KirBac1.1 tetramer stability.The Journal of biological chemistry · 2009Article
- Regulation of Ca2+ signaling with particular focus on mast cells.Critical reviews in immunology · 2009Review
- Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel.The Journal of physiology · 2005Article
- CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.The Journal of physiology · 2004Article
- Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Multigene family isoform profiling from blood cell lineages.BMC genomics · 2002Article
- Distinct properties of CRAC and MIC channels in RBL cells.The Journal of general physiology · 2002Article
- Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4.The Biochemical journal · 2001Article
- Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells.The Journal of physiology · 1999Article
- The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Inwardly rectifying potassium (IRK) currents are correlated with IRK subunit expression in rat nucleus accumbens medium spiny neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Inwardly rectifying whole cell potassium current in human blood eosinophils.The Journal of physiology · 1998Article
- Modulation of inwardly rectifying potassium channels in cultured bovine pulmonary artery endothelial cells.The Journal of physiology · 1997Article
- Corticotropin releasing hormone inhibits an inwardly rectifying potassium current in rat corticotropes.The Journal of physiology · 1997Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basophilic leucaemia cell line RBL-2H3 exhibits a robust inwardly rectifying potassium current, IKIR, which is likely to be modulated by G proteins. We examined the physiological and molecular properties of this KIR conductance to define the nature of the underlying channel species. The macroscopic conductance revealed characteristics typical of classical K+ inward rectifiers of the IRK type. Channel gating was rapid, first order (tau approximately 1 ms at -100 mV) and steeply voltage dependent. Both activation potential and slope conductance were dependent on extracellular K+ concentration ([K+]o) and inward rectification persisted in the absence of internal Mg2+. The current was susceptible to a concentration- and voltage-dependent block by extracellular Na+, Cs+ and Ba2+. Initial IKIR whole-cell amplitudes as well as current rundown were dependent on the presence of 1 mM internal ATP. Perfusion of intracellular guanosine 5'-Q-(3-thiotriphosphate) (GTP[gamma S]) suppressed IKIR with an average half-time of decline of approximately 400 s. It was demonstrated that the dominant IRK-type 25 pS conductance channel was indeed suppressed by 100 microM preloaded GTP[gamma S]. Reverse transcriptase-polymerase chain reactions (RT-PCR) with RBL cell poly(A)+ RNA identified a full length K+ inward rectifier with 94% base pair homology to the recently cloned mouse IRK1 channel. It is concluded that RBL cells express a classical voltage-dependent IRK-type K+ inward rectifier RBL-IRK1 which is negatively controlled by G proteins.
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