ArticlePflugers Archiv : European journal of physiology1995
Acetylcholine-induced currents in acutely dissociated sympathetic neurons from adult hypertensive and normotensive rats have similar properties.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Whole-cell patch-clamp recordings were used to compare the amplitude and kinetics of acetylcholine-induced currents (IACh) in acutely isolated superior cervical ganglion (SCG) neurons from spontaneously hypertensive (SHR) rats and Wistar-Kyoto (WKY) rats, to determine if altered postsynaptic transmitter responsiveness underlies the increased sympathetic nerve activity in SHR rat neurons. Rapidly activating and slowly inactivating inward currents were recorded in response to rapid application of ACh (5 microM to 2 mM). Concentration/response relationships for SCG neurons isolated for SHR and WKY rats had dissociation constants of 161 microM and 169 microM, maximum responses of 26 nS/pF and 24 nS/pF, and Hill coefficients of 1.8 and 1.9, respectively. Activation of the currents was fitted well by a single exponential function with concentration-dependent time constants, whereas inactivation was fitted well by a double exponential function also with concentration-dependent time constants. The time constants of both activation and inactivation for SHR and WKY rats were not significantly different at any concentration tested. The results demonstrate that the postsynaptic effects of ACh are similar between SHR and WKY rat postganglionic neurons and, therefore, probably do not contribute to the observed differences in ganglionic transmission between SHR and WKY rat nerves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.