ArticleThe Journal of physiology1995
Vasoreactivity to prostaglandins of rat peripheral nerve.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 13 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. We evaluated the effect of the local superfusion of prostaglandins E1, I2 and F2 alpha (PGE1, PGI2 and PGF2 alpha, respectively) on rat sciatic nerve blood flow and microvascular resistance. 2. PGE1 increased nerve blood flow (NBF) in a dose-dependent fashion with an EC50 of 10(-6.7) M and an asymptote of 20.1 ml (100 g)-1 min-1. 3. PGI2 increased NBF in a linear dose-dependent fashion, with an EC50 of 10(-5.1) M. PGI2 appeared to be about 1.5 orders of magnitude less potent than PGE1. 4. PGF2 alpha also increased NBF in a dose-dependent fashion. The threshold dose appeared to be identical with PGI2 but may have a reduced capacity of response. The EC50 of 10(-5.8) M was slightly lower than that of PGI2.
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